Effects of Sufentanil Target Controlled Infusion on Patient State Index Values and Electroencephalographic Spectrum During Total Intravenous Anesthesia With Propofol

University of Padova20 enrolled

Overview

Sufentanil Target Controlled infusion (TCI, Gepts model) effects on Neuromonitoring during Total Intravenous Anesthesia (TIVA) with Propofol TCI (Eleveld model) has not been investigate yet. Authors aim to investigate its effect on Patient State index (PSi), the power spectrum EEG, the Analgesia Nociception Index (ANI) nad pupillometry values during maintenance durin TIVA-TCI with Propofol and Sufentanil.

Sufentanil Target Controlled infusion (TCI, Gepts model) effects on Neuromonitoring during Total Intravenous Anesthesia (TIVA) with Propofol TCI (Eleveld model) has not been investigate yet. Authors aim to investigate its effect on Patient State index (PSi), the power spectrum EEG, the Analgesia Nociception Index (ANI) and pupillometry values during maintenance during TIVA-TCI with Propofol and Sufentanil.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Anesthesia Brain Monitor Sufentanil Target Controlled Infusion

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Undergo general anaesthesia with Targeted Controlled Infusion of Propofol (Eleveld model) and Sufentanil (Gepts model) Exclusion Criteria: * Neurological disease * Psychiatric disease * Obesity * Regional anesthesia performed

Outcomes

Primary Outcomes

Effects of Sufentanil on Patient State index (PSi) during stable Propofol general anesthesia

Evaluate if sufentanil variations during general anesthesia has an impact on the PSi values

Time frame: PSi values and Sufentanil Target Controlled Infusion (TCI) concentrations will be monitored during all the time of surgery

Effects of Sufentanil on Electroencephalogram (EEG) power spectrum during stable Propofol general anesthesia

Evaluate if sufentanil variations during general anesthesia has an impact on the EEG power spectrum

Time frame: EEG power spectrum and Sufentanil Target Controlled Infusion (TCI) concentrations will be monitored during all the time of surgery

Effects of Sufentanil on Analgesia Nociception Index (ANI) during stable Propofol general anesthesia

Evaluate if sufentanil variations during general anesthesia has an impact on the ANI values

Time frame: ANI values and Sufentanil Target Controlled Infusion (TCI) concentrations will be monitored during all the time of surgery

Secondary Outcomes

Analgesia Nociception Index (ANI) values and postoperative pain

Evaluate if different ANI values at the same Sufentanil concentrations has an impact on postoperative pain

Time frame: Numeric Rating Scale (NRS) will be evaluated after the end of surgery and 24 hours after the end of surgery and compared to ANI values after 24 hours

Patient State Index (PSi) values and postoperative delirium

Evaluate if different PSi values at the same Sufentanil concentrations has an impact on postoperative pain

Time frame: Confusion assessment method (CAM) test for delirium will be performed after the end of surgery and compared to PSi values after 24 hours

Analgesia Nociception Index (ANi) values and postoperative nausea and vomiting

Evaluate if different ANi values at the same Sufentanil concentrations has an impact on postoperative nausea and vomiting.

Time frame: Nausea and vomiting occurrence will be detected hours atend of surgery and compared to ANI values after 24 hours