TQ05105 Tablet for Myelofibrosis Treatment in Ruxolitinib-Resistant or Intolerant Patients

Inclusion Criteria: * Subjects voluntarily participated in this study, signed informed consent forms, and demonstrated good compliance； * Age: 18 or older (when signing the informed consent form); Eastern Cooperative Oncology Group (ECOG) performance status (PS) score of 0 or 2; Life expectancy ≥ 24 weeks; * Patients diagnosed with Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), or post essential thrombocythemia myelofibrosis (post-ET MF); * According to the dynamic international prognostic scoring system (DIPSS), patients with intermediate or high risk of bone marrow fibrosis were evaluated; * Patients with poor efficacy or intolerant of Ruxolitinib; * Spleen enlargement; * Peripheral blood primary cells and bone marrow primary cells were ≤10%; * No growth factor, colony stimulating factor, thrombopoietin or platelet transfusion was received within 2 weeks before the examination, and the blood routine indexes met the requirements within 7 days before the first administration; * The Main organ function is normal; * Men and women of childbearing age should agree to use contraceptive measures (such as intrauterine devices, contraceptives, or condoms) during the study period and within 6 months after the end of the study. Serum human chorionic gonadotrophin（HCG）test is not negative within 7 days before the first administration and must be non-lactating patients. Exclusion Criteria: * Patients who have previously received allogeneic stem cell transplantation, or received autologous stem cell transplantation within 3 months before the first administration, or recently planned stem cell transplantation; * Previous treatment with JAK inhibitors(except ruxolitinib); * Patients who have previously undergone splenectomy, or received splenic radiotherapy within 6 months before the first administration; * Other malignancies within 3 years prior to first administration or currently present; * Patients with multiple factors (such as inability to swallow, postoperative gastrointestinal resection, acute and chronic diarrhea, intestinal obstruction, etc.) affecting oral or absorption of drugs; * The non-hematological toxicity caused by previous treatment did not return to grade≤1; * Major surgical treatment or significant traumatic injury within 4 weeks prior to first administration; * Presence of congenital bleeding disorder and congenital coagulopathy; * Patients who had arterial/venous thrombosis events within 6 months before the first administration; * Have a history of mental drug abuse, or have a mental disorder; * Active or uncontrolled severe infection; * Active hepatitis B virus (HBV) infection, or hepatitis C virus (HCV) infection and HCV RNA positive; * Patients with ≥ grade 2 myocardial ischemia or myocardial infarction, arrhythmia, QT interval prolongation and ≥ grade 2 congestive heart failure; * Unsatisfactory blood pressure control despite standard therapy; * Patients with renal failure requiring hemodialysis or peritoneal dialysis; * Patients newly diagnosed with pulmonary interstitial fibrosis or drug-related interstitial lung disease within 3 months before the first administration; * Patients with a history of immunodeficiency disease or organ transplantation; * Patients with epilepsy requiring treatment; * Use of any MF medications, any immunomodulators, androgens, any immunosuppressive agents, erythropoietin, aspirin \> 100 mg/day within 2 weeks prior to first administration; * Patients who have received Chinese patent medicines with anti-tumor indications specified in the approved drug package insert of China National Medical Products Administration (NMPA) within 2 weeks before the first administration; * Patients with uncontrolled pleural effusion, pericardial effusion or ascites; * There was a history of attenuated live vaccine inoculation within 4 weeks before the first administration, or attenuated live vaccine inoculation was planned during the study period; * People with known hypersensitivity to the study drug and excipients; * Patients diagnosed as active autoimmune diseases within 2 years before the first administration; * Those who participated in and used other anti-tumor clinical trial drugs within 4 weeks before the first administration; * According to the judgment of the investigators, some situations seriously endanger the safety of the subjects or affect the subjects to complete the study.