Effect of Esketamine on Conscious State in Patients With pDoC

Inclusion Criteria: 1.16-65 years old 2.Native Chinese language 3.pDoC after acquired brain injury 4.Scheduled to undergo surgery 5.Signed informed consent Exclusion Criteria: 1. Continuous sedation treatment was carried out within 72 hours before the study 2. Airway stenosis and severe ventilation or ventilation dysfunction caused by various reasons 3. Known or suspected to have serious cardiac, pulmonary and renal dysfunction 1)Severe cardiac dysfunction: a. unstable coronary syndrome b. Congestive heart failure: left ventricular ejection fraction less than 50%, elevated BNP c.Severe arrhythmia d. History of severe valvular disease 2)Severe pulmonary dysfunction: a. history of pulmonary heart disease b. History of chronic obstructive pulmonary disease 3)Severe renal dysfunction: a. Endogenous creatinine clearance (Ccr) less than 30ml/min b. The glomerular filtration rate (GFR) was less than 30ml/min•1.73m2 4. Allergic history of sedative drugs 5. Combined with other mental or nervous system diseases 6. Other reasons are not suitable for this study.