This is a pilot, prospective, monocentric study concerning 15 Parkinson's disease patients requiring deep brain stimulation implantation. The primary objective is to evaluate the psychiatric lesion effects of deep brain stimulation in patients with Parkinson's disease, using the Young Mania Rating Scale (YMRS), Big Five Inventory and the Hamilton Depression Rating Scale (HAMD 21).
The patients included were adults suffering from Parkinson's disease (according to ICD-10). They had no severe psychiatric disorders, and no major neurocognitive disorders contraindicating surgery. An initial evaluation will be carried out 72 hours after surgery, then after one month, and finally 3 months after surgery.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
15
post-surgery behavioral assessment using scales
Marie Desbordes, MD
Sotteville-lès-Rouen, France
Assessment of change of mania symptoms
The variation of Young Mania Rating Scale (YMRS). The YMRS total score ranges from 0 to 60 where higher scores indicate more severe mania.
Time frame: Baseline, 72 hours, 1 month and 3 months after surgery
Assessment of change of depressive symptoms
The variation of Hamilton Rating Scale for Depression (HAMD-21). HAMD21 is a 21-item assessment used to measure depression severity. Items were rated on a scale from 0 (symptoms not present) to a maximum of 2 to 4 (symptom extremely severe) for a total score ranging from 0 (not at all depressed) to 64 (severely depressed).
Time frame: Baseline, 72 hours, 1 month and 3 months after surgery
Assessment of change of Behavior
The variation of the Ardouin Scale of Behavior in Parkinson's Disease. The total score ranges from 0 to 84. Higher score mean worse outcome.
Time frame: Baseline, 72 hours, 1 month and 3 months after surgery
Assessment of change of Impulsivity
The variation of the Dickman Impulsivity Inventory. It is a self report measure assessing dysfunctional impulsivity and functional impulsivity. Regarding dysfunctional impulsivity (12 items), higher score mean worse adaptation. Regarding functional impulsivity (11 items), higher score mean better adaptation.
Time frame: Baseline, 72 hours, 1 month and 3 months after surgery
Assessment of change of Apathy
The variation of the Apathy Evaluation Scale. This 18 item scale ranges from 0 to 12. Higher score means worse outcome.
Time frame: Baseline, 72 hours, 1 month and 3 months after surgery
Assessment of personality
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Big Five inventory. The test identified five factors as follows : * openness to experience (inventive/curious vs. consistent/cautious) * conscientiousness (efficient/organized vs. extravagant/careless) * extraversion (outgoing/energetic vs. solitary/reserved) * agreeableness (friendly/compassionate vs. critical/judgmental) * neuroticism (sensitive/nervous vs. resilient/confident)
Time frame: Baseline
Assessment of executive functions
Frontal Assessment Battery at Bedside. Thebattery consists of six subtests exploring the following: conceptualization, mental flexibility, motor programming, sensitivity to interference, inhibitory control, and environmental autonomy.
Time frame: Baseline, 72 hours, 3 months after surgery
Assessment of confusion
Confusion Assessment method (CAM). The CAM instrument assesses the presence, severity, and fluctuation of 9 delirium features: acute onset, inattention, disorganized thinking, altered level of consciousness, disorientation, memory impairment, perceptual disturbances, psychomotor agitation or retardation, and altered sleep-wake cycle.
Time frame: 72 hours and 3 months after surgery