This study was conducted to investigate the relationship between diastolic notching on uterine artery Doppler and serum apelin-13 and 36 concentrations between 11 and 14 weeks of gestation.
Apelin-13 and apelin-36, which provide vasodilatation through a nitric oxide-dependent mechanism, also play a role in trophoblasts' survival, proliferation, and migration. Based on this, we aimed to investigate serum apelin-13 and apelin-36 concentrations in pregnant women with and without diastolic notch on uterine artery Doppler between the 11th and 14th weeks of pregnancy. We hypothesized that apelin-13 and apelin-36 might be associated with the formation of diastolic notch in uterine artery Doppler and serum apelin-13 and apelin-36 concentrations would be lower in the group with a notch in the uterine artery Doppler than in the group without a notch.
Study Type
OBSERVATIONAL
Enrollment
88
there is no intervention in this study
Ümraniye Training and Research Hospital
Istanbul, Ümraniye, Turkey (Türkiye)
Relationship between diastolic notching on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations.
Relationship between diastolic notching on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations.
Time frame: through study completion, an average of 1 year
Relationship between high pulsatility index on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations.
Relationship between high pulsatility index on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations.
Time frame: through study completion, an average of 1 year
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