Clinical Performance of the Therapy Option FlexPoint of the PD Cycler Sleep•Safe Harmony

Inclusion Criteria: * Informed consent signed and dated by study patient and investigator/ authorised physician * Minimum age of 18 years * CKD patients with indication for renal replacement therapy * Patients being treated with APD for at least 3 months * Patients using the sleep•safe harmony PD cycler (version 3.1) * Fluid status regularly monitored with Body Composition Monitor (BCM) * Proper functioning catheter * Intraperitoneal Pressure (IPP) ≤ 18 cm H2O * Ability to understand the nature and requirements of the study Exclusion Criteria: * Any conditions which could interference with the patient's ability to comply with the study * Previous participation in the same study * Patients who have any condition prohibiting the use of BCM, like patients with major amputations (e.g. lower leg) * Patients receiving polyglucose containing PD solution * Respiratory or abdominal wall disease deemed to contraindicate intraperitoneal fill volume (FV) manipulation * Patients who suffer from peritonitis/exit site infection during the last 4 weeks * Women of childbearing age without effective means of contraception, pregnancy (pregnancy test will be conducted at start and end of study) or lactation period * Life expectancy \<3 months * Participation in an interventional clinical study during the preceding 90 days