The prospective observational study delves into the complex relationship between neuroinflammation and oxidative stress in post-cardiac surgery complications, focusing on postoperative cognitive dysfunction.
The prospective observational study meticulously examines the interplay between neuroinflammation and oxidative stress in the realm of post-cardiac surgery complications, specifically targeting postoperative cognitive dysfunction. Its primary objective is to comprehensively assess the sustained influence of these intricate processes on cognitive function and overall well-being, extending beyond the immediate aftermath of surgery. The research endeavors to probe deeply into the molecular mechanisms and clinical ramifications associated with neuroinflammation and oxidative stress, centering on their pivotal role in shaping the onset and trajectory of postoperative cognitive dysfunction.
Study Type
OBSERVATIONAL
Enrollment
60
extracorporeal circulation during cardiosurgical operation
Europainclinics
Košice, Slovakia
RECRUITINGNumber and type of early complications after surgery
Estimating of postoperative complications
Time frame: 1 month
Number and type of postoperative complications
Estimating of postoperative complications
Time frame: 6 months
Estimating biochemical parameters
Pro-inflammatory interleukins parameters (e.g. IL-8, IL-6, MIP-1a, MMP-2, MMP-9, SIRT 1, SIRT 2)
Time frame: 1 hour
Estimating biochemical parameters
Pro-inflammatory interleukins
Time frame: 6 hours
Estimating biochemical parameters Third biochemical examination
Antioxidative enzymes
Time frame: 1 hour
Estimating biochemical parameters
Antioxidative enzymes
Time frame: 6 hours
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