This study aims to develop and validate a Random Survival Forest (RSF) model for predicting long-term survival in elderly patients following curative resection for gastric cancer. The study is a retrospective multi-center analysis involving patients aged 75 and above who underwent gastric resection from January 2009 to December 2018 at nine top-tier hospitals in China. An online prognostic tool is introduced to assist clinicians in predicting patient prognosis and customizing treatment and follow-up strategies.
This retrospective multi-center study focuses on the development and validation of a predictive model for elderly gastric cancer patients. Data were collected from 16,344 gastric cancer patients, with 1,202 elderly patients ultimately included after applying exclusion criteria. Patients were randomly divided into training and testing cohorts in a 7:3 ratio. The study was approved by the institutional review boards with a waiver of informed consent due to the use of anonymized secondary data. The analysis employs the Random Survival Forest (RSF) method, incorporating variable importance and minimal depth techniques to select key variables for predicting overall survival (OS) and disease-free survival (DFS). The study also implements rigorous data handling procedures, including multiple imputations for missing data. The development of an online prognostic tool based on the RSF model is part of the project, designed to provide real-time survival predictions through a user-friendly interface for clinical application.
Study Type
OBSERVATIONAL
Enrollment
1,202
Department of Gastric Surgery， Fujian Medical University Union Hospital
Fuzhou, Fujian, China
5-Year Overall Survival
The proportion of patients who are alive at five years after treatment for elderly gastric cancer patients.
Time frame: 5 years or 60 months.
5-Year Disease-Free Survival
The proportion of patients who have survived without any signs or symptoms of gastric cancer for five years after the initial treatment.
Time frame: 5 years or 60 months.
3-Year Overall Survival
The proportion of patients who have survived without any signs or symptoms of gastric cancer for 3 years after the initial treatment.
Time frame: 3 years or 36 months.
1-Year Overall Survival
The proportion of patients who have survived without any signs or symptoms of gastric cancer for 1 years after the initial treatment.
Time frame: 1 years or 12 months.
3-Year Disease-Free Survival
The proportion of patients who have survived without any signs or symptoms of gastric cancer for 3 years after the initial treatment.
Time frame: 3 years or 36 months.
1-Year Disease-Free Survival
The proportion of patients who have survived without any signs or symptoms of gastric cancer for 1 years after the initial treatment.
Time frame: 1 years or 12 months.
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