Opioid Free Anesthesia in Abdominal Laparoscopic Surgery

Indonesia University74 enrolled

Overview

Effectiveness of opioid free anesthesia using Dexmedetomidine to inhibit nociception in abdominal laparoscopic surgery

Abdominal laparoscopic surgery is one of the most common procedures worldwide, commonly facilitated with opioid balanced anesthesia or regional anesthesia. Despite being a controversy, there are issues that suggest opioid to have an influence in tumor recurrence. The investigators performed general anesthesia without opioid in laparoscopic abdominal surgery, and compared the hemodynamic instability, total consumption of fentanyl rescue, qNOX score, Ephedrine intraoperative, and Numerical Rating Scale.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Laparoscopic Surgery Abdominal Surgery

Interventions

DexmedetomidineDRUG

OFA

FentanylDRUG

Given as analgesia in opioid balanced anesthesia (control) group

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion criteria * Patients undergoing abdominal laparoscopic surgery (digestive, urologic, gynecologic surgery) with general anesthesia * BMI \<= 30 kg/m2 * Assessed with ASA 1-3 * Willing to participate in this study Exclusion Criteria: * Allergy to dexmedetomidine * Heart rate \< 60 or systolic blood pressure \<100 mmHg * Severe cardiovascular, uncontrolled hypertension (stage 2) or hepatic or renal disorder * Sepsis * Pregnancy * Difficult airway Drop out Criteria: * Intraoperative emergency * Convert to open laparatomy * Decided to withdraw from the study

Locations (1)

Cipto Mangunkusumo Cental National Hospital

Jakarta, DKI Jakarta, Indonesia

Outcomes

Primary Outcomes

Blood pressure

blood pressure, both systolic and diastolic measured with non invasive blood pressure monitoring

Time frame: Intraoperative

Heart rate

Time frame: Intraoperative

Secondary Outcomes

Total consumption of Opioid

Total consumption of fentanyl as rescue analgesia in mcg

Time frame: Intraoperative

quantium nociception index (qNOX)

qNox score is measured at specific time points, available from Conox monitor measurement since the start of the procedure. Higher value indicates more nociception experienced by the patient (0-100)

Time frame: Intraoperative

Ephedrine

Total consumption of ephedrine to increase heart rate and blood pressure in mg

Time frame: intraoperative

Pain score

Numerical rating scale 0-10 is used to quantify pain score postoperatively, with higher value indicating more pain experienced by the patient

Time frame: 24 hour

Data from ClinicalTrials.gov

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