The objective of this observational clinical study is to evaluate the variations in ascorbic acid during the transplantation phases and how these variations influence the oxidative status and patient outcome. The main questions it aims to answer are: * how many patients arrive at the transplant in a state of hypovitaminosis C? * how does hypovitaminosis C affect the patient's oxidative status? * how does hypovitaminosis C affect the length of stay in intensive care and post-transplant complications?
Researches will compared: Differences between Hypovitaminosis Group and Normal Range Group Changes in oxidative stress markers before and after solid organ transplantation Incidence of allograft dysfunction between groups Incidence of acute kidney injury and other complications between groups
Study Type
OBSERVATIONAL
Enrollment
40
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano
Milan, Italy
Ascorbic Acid levels
Quantification of plasma ascorbic acid levels before and after liver/kidney/lung transplantation
Time frame: At induction of anesthesia for TX, within 24h from ICU admission, 72 hours after transplantation, 7 days after transplantation
Reactive Oxygen Species (ROS) levels
Quantification of ROS before and after liver/kidney/lung transplantation
Time frame: At induction of anesthesia for TX, within 24 hours from ICU admission, 72 hours after transplantation, 7 days after transplantation
Total Antioxidant Capacity (TAC) levels
Quantification of TAC before and after liver/kidney/lung transplantation
Time frame: At induction of anesthesia for TX, within 24 hours from ICU admission, 72 hours after transplantation, 7 days after transplantation
8-hydroxydeoxyguanosine (8-OHdG) levels
Quantification of 8-OHdG before and after liver/kidney/lung transplantation
Time frame: At induction of anesthesia TX, within 24 hours from ICU admission, 72 hours after transplantation, 7 days after transplantation
Mechanical ventilation
Duration of mechanical ventilation (days) until extubation of the recipient
Time frame: From ICU admission until extubation occurs, assessed daily up to 100 days from transplantation
Length of Intensive Care Unit (ICU) stay
Length of ICU stay
Time frame: From ICU admission until ICU discharge occurs, assessed daily up to 100 days from transplantation
Allograft dysfunction
Incidence of early allograft dysfunction (EAD in liver recipients), primary graft dysfunction (PGD in lung recipients), delayed graft function (DGF in kidney recipients)
Time frame: Within the first 7 days after transplantation
Mortality in Intensive Care Unit (ICU)
Incidence of death for any cause during ICU stay
Time frame: From ICU admission until ICU discharge occurs, assessed daily up to 100 days from transplantation
Length of hospitalization
Length of stay in hospital (days)
Time frame: From ICU admission until hospital discharge occurs, assessed daily up to 100 days from transplantation
Acute kidney injury (AKI)
Incidence of postoperative renal injury after liver/kidney/lung transplantation as Kidney Disease Improving Global Outcomes (KDIGO) criteria
Time frame: Worst kidney function within the first 7 days after TX
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