The investigators aim to elucidate characteristics of structural and functional brain connectivity in patients with amyotrophic lateral sclerosis (ALS) and pseudobulbar affect (PBA) using diffusion kurtosis imaging (DKI) and magnetoencephalography (MEG).
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
50
Non-invasive MRI sequence which extracts information of diffusion signals from complex brain tissue
Non-invasive method of measuring resting state brain activity through magnetoencephalography (MEG)
Aalborg University hospital
Aalborg, Northern Jutland, Denmark
RECRUITINGMean kurtosis
A measurement of kurtosis diffusion signal in pseudobulbar affect-affiliated brains areas (prefrontal lobe, pons, cerebellum, motor cortex, temporal lobe) derived from Diffusion kurtosis imaging (DKI)-MRI
Time frame: Baseline measurement and up to 6 month follow-up measurements
Spectral connectivity
Estimation of connectivity (correlation between spikes of activity) between pseudobulbar affect afflilated cortical brain areas (prefrontal cortex, motor cortex, temporal lobe) derived through resting state magnetoencelphalography (MEG)
Time frame: Baseline measurement and up to 6 month follow-up measurements
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