Atrial fibrillation (AF) is a leading cause of cardiovascular mortality and morbidity. Asian patients with AF have a higher rate of major bleeding including intracranial hemorrhage (ICH) compared to non-Asians. Non-vitamin K antagonist oral anticoagulants (NOACs) are the safer drugs compared to warfarin due to a lower rate of ICH, but the rate of NOACs use in many Asian AF is much lower than non-Asian countries due to economic concerns. The purpose of the COhort of antithrOmbotic use and cLinical outcomes in patients with Atrial Fibrillation (COOL-AF) Phase 2 registry is to determine the changes in antithrombotic patterns and the impact on clinical outcomes. The COOL-AF Phase 2 study is a prospective observational multicenter study of patients with known or newly diagnosed non-valvular AF in Thailand. The aim is a sample size is 3680 patients from 33 centers within a 2-years enrollment timeline. Patients will be follow-up every 6 months until 3 years. The study outcomes were death, ischemic stroke/systemic embolism, major bleeding, myocardial infarction, heart failure, and quality of life.
Study Type
OBSERVATIONAL
Enrollment
4,000
No intervention
Faculty of Meddcine Siriraj Hospital, Mahidol University
Bangkok, Bangkok, Thailand
RECRUITINGFaculty of Medicine, Chulalongkorn University,
Bangkok, Bangkok, Thailand
RECRUITINGFaculty of Medicine, Ramathibodi Hospital, Mahidol University
Bangkok, Bangkok, Thailand
RECRUITINGFaculty of Medicine, Vajira Hospital, Navamindradhiraj University
Bangkok, Bangkok, Thailand
Rate of warfarin and NOACs use
Time frame: 3 years
Rate of ischemic stroke/TIA
Time frame: 3 years
Rate of systemic embolism
Time frame: 3 years
Rate of intracranial hemorrhage
Time frame: 3 years
Rate of major bleeding
Time frame: 3 years
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