To evaluate the degree of acute and long-term intestinal, urinary and vaginal toxicity, and the impact on sexual activity of an accelerated fractionation of high dose rate interventional radiotherapy (IRT-HDR) in patients with locally advanced cervical cancer (IB2 - VA, N+/-).
Observational, monocentric and prospective study. All patients with locally advanced cervix cancer will be underwent to radiochemotherapy followed by accelerated interventional radiotherapy (brachytherapy). Fist endpoints wer severe acute and late gastrointestinal, and urinary toxicities and sexual activity.
Study Type
OBSERVATIONAL
Enrollment
129
The patients will undergo four IRT fractions in one week
Fondazione Policlinico Universitario A. Gemelli, IRCCS
Rome, Italy
RECRUITINGAcute and late gastrointestinal toxicity
Acute and late toxicities will evaluated with CTCAE scale to analyze the safety of accelerated interventional radiotherapy
Time frame: 6 months
Acute and late urinary toxicity
Acute and late urinary toxicities will evaluated with CTCAE scale to analyze the safety of accelerated interventional radiotherapy
Time frame: 6 months
Sexual activity
Sexual activity will evaluated with CTCAE scale to analyze the safety of accelerated interventional radiotherapy
Time frame: 6 months
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