Prediction of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma Based on Ultrasound and Cytological Images

Nanchong Central Hospital1,500 enrolled

Overview

Rising thyroid carcinoma rates, with papillary thyroid carcinoma (PTC) as the main type (85-90% of cases), often show early cervical lymph node spread. This increases the risk of PTC patients for recurrence and death. A new study's multimodal model fuses preoperative US and cytology images to better predict lymph node metastasis, aiming to improve treatment plans, reduce unnecessary surgeries, and enhance patient outcomes.

Thyroid carcinoma incidence has been on the rise in recent years. Papillary thyroid carcinoma is the most prevalent type of differentiated thyroid carcinoma, accounting for 85% to 90% of malignant thyroid tumors. Despite its indolent nature, cervical lymph node metastasis is frequently observed at an early stage. Papillary thyroid carcinoma patients with cervical lymph node metastasis face an elevated risk of recurrence, distant metastasis, and mortality. Thus, non-invasive preoperative prediction of cervical lymph node metastasis is particularly vital for guiding treatment plans and prognostic. this study has developed a multimodal model integrating preoperative US images with cytological images of papillary thyroid carcinoma patients. The aim is to enhance the predictive accuracy for cervical lymph node metastasis, reduce unnecessary lymph node dissections, and provide real-time, precise guidance for determining the extent of surgical resection and prognostic assessment. This approach aims to optimize patient treatment strategies and enhance therapeutic outcomes.

Study Type

OBSERVATIONAL

Enrollment

1,500

Conditions

Papillary Thyroid Carcinoma Lymph Node Metastasis

Interventions

Thyroidectomy and lymph node dissectionPROCEDURE

All surgical specimens of thyroidectomy and lymph node dissection were subjected to paraffin-embedded histopathological examination, and postoperative were categorized as with cervical lymph node metastasis and without cervical lymph node metastasis.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Underwent thyroidectomy and bilateral lymph node dissection with pathological confirmation of PTC * Completed US examination within one week before surgery * Underwent preoperative us-guided FNAC * Completed cytological images at 400× magnification under a microscope Exclusion Criteria: * Patients who underwent only unilateral thyroidectomy * Patients with cervical lymph nodes shown on preoperative ultrasound

Locations (1)

Nanchong central hospital

Nanchong, Sichuan, China

Outcomes

Primary Outcomes

Presence or absence of lymph node metastasis

All surgical specimens were subjected to paraffin-embedded histopathological examination，depending on the pathological findings, it is classified as the presence or absence of lymph node metastases.

Time frame: October 2024

Data from ClinicalTrials.gov

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