The goal of this observational cohort study is to identify and predict parameters for successful testicular sperm extraction (TESE) procedures or semen cryopreservation more accurately and to evaluate the decision making process and the experience of postponing or temporarily discontinuing puberty suppression to undergo successful fertility preservation. in transfeminine (assigned male at birth) adolescents. The main question\[s\] it aims to answer are: * What is the optimal timing for fertility preservation before the start or after temporarily discontinuing puberty suppression puberty suppression * How do transfeminine adolescents and their parents experience the decision making process of fertility preservation * how do transfeminine adolescents and their parents experienced postponing or temporarily discontinuing puberty suppression to undergo successful fertility preservation? Participants will be asked to use their medical data, answer a questionnaire or participate in a (online) interview.
Study Type
OBSERVATIONAL
Enrollment
40
Amsterdam UMC, location AMC
Amsterdam, Netherlands
RECRUITINGAmsterdam UMC, Location VU Medical Center
Amsterdam, Netherlands
RECRUITINGWhat parameter is best in predicting successful fertility preservation (i.e. spermatazoa are present)
Testicular volume
Time frame: Most recent before the TESE of semen cryopreservation no longer than 3 months old
What parameter is best in predicting successful fertility preservation (i.e. spermatazoa are present)
serum testosteron
Time frame: Most recent before the TESE of semen cryopreservation no longer than 3 months old
What parameter is best in predicting successful fertility preservation (i.e. spermatazoa are present)
serum LH
Time frame: Most recent before the TESE of semen cryopreservation no longer than 3 months old
What parameter is best in predicting successful fertility preservation (i.e. spermatazoa are present)
Serum FSH
Time frame: Most recent before the TESE of semen cryopreservation no longer than 3 months old
What parameter is best in predicting successful fertility preservation (i.e. spermatazoa are present)
Serum SHBG
Time frame: Most recent before the TESE of semen cryopreservation no longer than 3 months old
How do adolescents and parents experience fertility preservation
self-constructed questionnaires and semi-structed interviews
Time frame: After refferal to fertility preservation specialist, after every 3 months after the start of Tanner 2, 1 month after the fertility preservation.
How do adolescents and parents experience fertility preservation
semi-structed interviews
Time frame: 1 month post fertility preservation
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