This study aims to evaluate the impact of Sodium-dependent glucose transporters 2 inhibitor Empagliflozin on the exercise capacity,symptoms of heart failure, cardiac function, myocardial remodeling and quality of life of nonobstructive HCM patients with HFpEF.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
94
Participants randomized to the study group will received Empagliflozin 10mg q.d. for 12 months.
Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College
Beijing, Beijing Municipality, China
RECRUITINGVO2max on cardiopulmonary exercise tesing
Time frame: 12 months
NT-ProBNP
Time frame: 12 months
NYHA heart failure classification
Time frame: 12 months
KCCQ-CSS
Time frame: 12 months
HCMSQ-(SoB)
Time frame: 12 months
E/A
Time frame: 12 months
E/e'
Time frame: 12 months
Peak tricuspid regurgitation velocity
Time frame: 12 months
Left atrium volume index , LAVI
Time frame: 12 months
Left Ventricular Mass index, LVMI
Time frame: 12 months
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