The supplementation of hydrogen molecules as an aid, adjuvant, may speed up recovering the course of the disease. The purpose of this study is to determine the possible efficacy and safety of solid hydrogen supplements for a clinical study in patients with chronic diseases. Patients will receive hydrogen capsules with their conventional treatment for 24 weeks. Investigators will test for any changes in haematologic, urine analysis and health status during and following the exposure period.
Hydrogen supplement has been shown to have significant removing effects on free radicals. International clinical trials have shown promise that hydrogen molecules may reduce chronic inflammatory and then speed up recovering the course of the disease.The purpose of this study is to determine the possible efficacy and safety of hydrogen supplements in different formula and dose exposures for a clinical study in patients with chronic diseases.Study design: 60 chronic diseases patients will be recruited from the Taoyuan Armed Forces General Hospital and Tri-Service General Hospital for this study. Participants will be screened by doctors for their eligibility and undergo a series of tests (questionnaires and examinations).Consenting participants will then be randomly allocated into 2 groups (experiment group and control group, single-blind study). In experiment group, participants will receive 2 solid hydrogen capsules every day for 24 weeks. In control group, participants will receive 2 capsules not containing hydrogen every day for 24 weeks. Participants will be examined their regular haematology, urine and health status before and after the intervention.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
60
In experiment group, participants will receive 2 solid hydrogen capsules every day for 24 weeks. In control group, participants will receive 2 capsules not containing hydrogen every day for 24 weeks.
Tri-Service General Hospital
Taipei, Taiwan
RECRUITINGTaoyuan Armed Forces General Hospital
Taoyuan District, Taiwan
RECRUITINGImprovement in Blood Routine
Change in Blood Routine, including WBC, RBC, HGB, HCT, MCV, MCH, MCHC, PLT, Lymphocyte, Monocyte, Eosinophil, Basophil, Neutrophil, Triglyceride, Cholesterol, HDL, LDL, ESR, and CRP
Time frame: Change from Baseline of Blood Routine, and every return per 4 weeks during 24 weeks of the intervention
Improvement in Urine Routine
Change in Urine Routine, including GLU, PRO, BIL, URO, PH, SG, OB, KET, NIT, Uric acid, BUN, and eGFR
Time frame: Change from Baseline of Urine Routine, and every return per 4 weeks during 24 weeks of the intervention
Improvement in the Health Assessment Questionnaire Disability Index (HAQ-DI) Questionnaire
Change in the (HAQ-DI) Questionnaire
Time frame: Change from Baseline of HAQ-DI, and every return per 4 weeks during 24 weeks of the intervention
Improvement in the Disease Activity Score (DAS 28)
Change in the DAS 28
Time frame: Change from Baseline of DAS 28, and every return per 4 weeks during 24 weeks of the intervention
Improvement in the Brief Fatigue Inventory-Taiwan (BFI-T)
Change in the BFI-T
Time frame: Change from Baseline of BFI-T, and every return per 4 weeks during 24 weeks of the intervention
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