Endoscopic retrograde cholangiopancreatography (ERCP) procedure is frequently encountered in non-operating room anesthesia applications (NORA). It is a procedure that requires deep sedation and analgesia in terms of gastroenterologist and patient comfort. Dexmedetomidine, which is increasingly used in NORA applications, comes to the fore because it does not cause respiratory depression, reduces the stress response, and provides hemodynamic stability. This study aims to compare the effects of dexmedetomidine-propofol (DP) and remifentanil-propofol (RP) combinations on hemodynamic stability, rapid recovery, and patient comfort in patients who underwent ERCP.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
76
Group DP received 0.5 mcg/kg of dexmedetomidine IV for 30 seconds, then dexmedetomidine infusion was started at 0.1-0.7 mcg/kg/h. Propofol 1 mg/kg was administered after waiting for 5 minutes for adequate sedation to develop due to dexmedetomidine's delayed onset of action.
Group RP received remifentanil 0.1 mcg/kg intravenously for 30 seconds, then remifentanil infusion was started at 0.01-0.1 mcg/kg/min. After waiting 2 minutes to develop a sufficient sedation level, 1 mg/kg of propofol was given.
Baskent University Ankara Hospital
Ankara, Cankaya, Turkey (Türkiye)
Agitation-Sedation
It will be evaluated with a Richmond Agitation-Sedation Scale.
Time frame: 0 and 5 minutes after ERCP ends
Hemodynamic stability
Mean arterial pressure with non-invasive blood pressure monitoring (mmHg)
Time frame: 5, 10, 15, 25, 35. minutes
Minimize drug dose
Amounts of medication administered throughout the procedure period will be collected.
Time frame: 5, 10, 15, 25, 35. minutes
Patient comfort
It will be evaluated by nausea-vomiting and survey.
Time frame: 30 minutes after ERCP ends
Rapid recovery
It will be evaluated with a Modified Aldrete Score.
Time frame: 30 minutes after ERCP ends
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