A growing body of evidence supports associations between cardiovascular health and adverse pregnancy outcome and between adverse pregnancy outcome and atherosclerotic cardiovascular disease and builds on the well-established pathways known to exist between cardiovascular health and atherosclerotic cardiovascular disease across the life course and intergenerationally. Furthermore, previous studies frequently lack comprehensive long-term follow-up, making it difficult to assess the enduring impacts of maternal cardiovascular health on postpartum outcomes and long-term maternal and child health.
the current study aimed to evaluate the associations between maternal pre-existent atherosclerotic cardiovascular disease and adverse pregnancy outcomes, and the combined effect of maternal pre-existent atherosclerotic cardiovascular disease and adverse pregnancy outcomes on the risk of long-term adverse events of offspring.
Study Type
OBSERVATIONAL
Enrollment
5,461,222
Presence of pre-existing atherosclerotic cardiovascular disease
Samsung Medical Center
Seoul, South Korea
RECRUITINGOccurence of post-partum MACCE
major adverse cardiac and cerebrovascular event
Time frame: up to 5 years
Occurence of All-cause death
Death from any causes
Time frame: up to 5 years
Occurence of myocardial infarction
Myocarrdial infarction
Time frame: up to 5 years
Occurence of revascularization
percutaneous coronary intervention or coronary artery bypass grafting
Time frame: up to 5 years
Occurence of stroke
Ischemic or hemorrhagic stroke
Time frame: up to 5 years
Occurence of adverse pregnancy outcome
preterm delivery, pre-eclampsia or eclampsia, other hypertensive disorder of pregnancy, small-for-gestational-age, and gestational diabetes
Time frame: At delivery
Occurence of major congenital malformation in offspring
congenital malformation in offspring
Time frame: At delivery
Occurence of neonatal adverse events in offspring
transient tachypnea, respiratory distress syndrome, necrotizing enterocolitis, intraventricular hemorrhage, bronchopulmonary dysplasia, and sepsis
Time frame: within 30 days
Occurence of adverse infant events in offspring
admission to intensive care unit and occurrence of seizure events
Time frame: Within 1 year
Occurence of neurodevelopmental disorders
autism spectrum disorder, attention-deficit/hyperactivity syndrome, cerebral palsy, any developmental delay including motor or cognitive delay, epileptic and febrile seizures and tics, and stereotypic behavior
Time frame: up to 5 years
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