Comparison of the Effects of Single Versus Triple Injections of Platelet-Rich Plasma in Patients With Knee Osteoarthritis

Izmir Democracy University80 enrolled

Overview

80 patients diagnosed with knee osteoarthritis were randomized into two groups: patients in Group 1 received a single intraarticular injection of PRP whereas those in group 2 were administered three intraarticular injections of PRP within an interval of 2 weeks between each application. Patients were evaluated before the treatment and at the 6 month after the treatment with a Visual Analog Scale (VAS) and The Western Ontario and MacMaster Universities (WOMAC) Osteoarthritis Index.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Knee Osteoarthritis

Interventions

prp injectionOTHER

intraarticular prp

Eligibility

Sex: ALLMin age: 35 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ages of 35 and 80 * Kellgren-Lawrence grade of 2, 3, or 4 Exclusion Criteria: * rheumatic diseases, coagulopathies, severe cardiovascular diseases, local infections, malignancies, immunodeficiency, schizophrenia, mental retardation, anticoagulant therapy, a hemoglobin concentration of 11 g/dL and platelets of 150,000/L, a history of severe trauma, or a history of hyaluronic acid or corticosteroid injection within the previous 6 months

Locations (1)

Buca Seyfi Demirsoy Training and Research Hospital

Izmir, Turkey (Türkiye)

Outcomes

Primary Outcomes

The Western Ontario and MacMaster Universities (WOMAC) Osteoarthritis Index

Time frame: baseline and 6 months

Secondary Outcomes

Visual Analog Scale (VAS)

Time frame: baseline and 6 months

Data from ClinicalTrials.gov

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