Assessment of Hypoxia Inducible Factor and Autophagy Related Genes in Patients With Non-Segmental Vitiligo

Sohag University30 enrolled

Overview

The present study will aim to evaluate: 1. The presence of Hypoxia Inducible Factor in vitiligo patient 2. Defect of Autophagy Related Genes in vitiligo patient 3. The cross relation between Autophagy Related Genes and Hypoxia Inducible Factor in the pathogenesis of vitiligo among Egyptian patients in Sohag Governorate

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Vitiligo

Interventions

Punch Biopsy 5mmDEVICE

Disinfect the skin, inject local anesthesia ,insert the punch and extract the biopsy

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adult \>18 years * With non segmental vitiligo * A group of participants will be included as a control group Exclusion Criteria: * Pregnancy * Patient with chronic inflammatory skin disorders * patient on anti-oxidant or anti-inflammatory drugs * patient on topical or systemic treatment for vitiligo in last 4 weeks * patients with other autoimmune diseases * patients with diabetes mellitus

Locations (1)

Sohag University hospitals

Sohag, Egypt

RECRUITING

Outcomes

Primary Outcomes

Assessment of Autophagy Related genes in Vitiligo patients

Assess Autophagy Related genes levels in skin biopsy of vitiligo patient

Time frame: 2 months

Assessment of Hypoxia Inducible Factor in Vitiligo patients

Assess level of Hypoxia Inducible factor in skin biopsy of vitiligo patient

Time frame: 2 months

Central Contacts

Rania H Metwally, Resident

CONTACT

01018845428 rania_hassan_post@med.sohag.edu.eg

Reham E El-Sharkawy, Professor

CONTACT

01006809003

Data from ClinicalTrials.gov

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