Device-related Central Nervous System Infections in Adult Intensive Care Units in Brazil

N/AActive Not RecruitingNCT06412523

Beneficência Portuguesa de São Paulo554 enrolled

Overview

Resistant microorganisms are public health problems because they affect the treatment of infectious diseases and the survival of patients. Neurosurgical procedures with placement of intracranial pressure monitoring and external ventricular drainage devices are related to increased morbidity and mortality. In Brazil, there are several multicenter studies demonstrating the prevalence and types of resistant microorganisms, however, there is a lack of data related to central nervous system infections associated with invasive devices, which can have a direct impact on prevention and treatment policies.

Neurosurgical procedures with placement of devices are related to increased morbidity and mortality. A study shows that the incidence of device-related central nervous system infection can reach 27%. A meta-analysis published in 2015, which included 35 studies, showed an incidence of 11.4 per 1000 catheters-day. This is a prospective cohort study, including adult patients, in the ICUs of hospitals participating in the IMPACTO MR Platform, who have a catheter device for monitoring intracranial pressure or external ventricular shunt, with infection densities and microbiological profile being evaluated; risk factors; clinical management; costs involved and short- and long-term clinical outcomes

Study Type

OBSERVATIONAL

Enrollment

554

Conditions

Central Nervous System Infections

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All patients over 18 years of age admitted to the ICU in the selected hospitals during the study period, using intracranial pressure monitoring catheters and/or external ventricular shunt. Exclusion Criteria: * Diagnosis of brain death.

Locations (18)

Unimed Vitória

Vitória, Espírito Santo, Brazil

Hospital Geral Cleriston Andrade

Feira de Santana, Estado de Bahia, Brazil

Hospital da Cidade

Salvador, Estado de Bahia, Brazil

Santa Casa de Belo Horizonte

Belo Horizonte, Minas Gerais, Brazil

Santa Casa de Misericórdia de Passos

Passos, Minas Gerais, Brazil

Santa Casa de Misericórdia de São João del Rei

São João del Rei, Minas Gerais, Brazil

Instituto Estadual do Cérebro Paulo Niemeyer (Pró Saúde- Associação Beneficente de Assistência Social e Hospitalar)

Rio de Janeiro, Rio de Janeiro, Brazil

Hospital Universitário Onofre Lopes

Natal, Rio Grande do Norte, Brazil

Hospital de Clinicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Instituto Baía Sul de Ensino e Pesquisa Irineu May Brodbeck

Florianópolis, Santa Catarina, Brazil

...and 8 more locations

Outcomes

Primary Outcomes

Incidence density of central nervous system infection

Incidence density will be reported as number of CNS infections per 1000 catheters/day, together with 95% CI. Cumulative incidence will also be reported.