Vit D and Post-extractive Bone Turnover

Studio Odontoiatrico Associato Dr. P. Cicchese e L. Canullo14 enrolled

Overview

The aims of the study was to correlate the extent of the dimensional alveolar bone changes after tooth extraction and contextual guided bone regeneration with serum vit D levels in 14 patients. Moreover, at 4 months, a small bone sample was collected in order to correlate histological and immunohistochemical parameters of bone with vit D serum levels.

The study included 14 patients requiring tooth extraction and subsequent post-extraction bone regeneration with heterologous graft material of porcine origin. Four months after extraction, dental implants were placed, and insertion torque values (ITV) and implant stability quotients (ISQ) were recorded. During implant placement, a small bone sample was collected for histological analysis. The aim of the study was to analyze the correlation between serum vitamin D levels and post-extraction bone volume contraction, collagen type I (Col1A1), osteocalcin, osteopontin, runt-related transcription factor 2 (Runx2), ITV, ISQ, Newly Formed Bone Tissue (NFBT).

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Vitamin D Deficiency Alveolar Bone Loss Alveolar Bone Resorption

Interventions

Tooth extraction, guided bone regeneration and dental implantPROCEDURE

The arm received tooth extraction and contextual guided bone regeneration. After 4 months, a dental implant was inserted.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male or female adult (≥ 18 years old) * Patients willing to participate and to attend the planned follow-up visits Exclusion Criteria: * Absence of Type 1-Medical conditions requiring prolonged use of steroids and/or medications that can interfere with bone metabolism * History of leukocyte dysfunction and deficiencies * History of neoplastic disease requiring the use of radiation or chemotherapy * History of renal failure * Metabolic disorders such as osteoporosis and correlated vit D or antiresorptive medications assumption * Physical handicaps that would interfere with the ability to perform adequate oral hygiene * History of uncontrolled endocrine disorders * Alcoholism or any drug abuse * History of immunodeficiency syndromes * Smoker of 10 cig per day, cigar equivalents or tobacco chewers * Conditions or circumstances which in the opinion of the investigator would prevent completion of study participation or interfere with the analysis of the study results, such as history of non-compliance or unreliability * Mucosa disease such as erosive lichen planus * Residual post-extraction site with intact bone walls * History of local irradiation therapy * Persistent intraoral infection

Locations (1)

Studi Odontoiatrici Luigi Canullo

Roma, RM, Italy

Outcomes

Primary Outcomes

Dimensional alveolar bone changes

Volumetrical changes of alveolar bone after tooth extraction measured by superimposition of two intraoral scans. The first was registered before the extraction of the tooth. The second was registered after 4 months (before inserting implant). The parameter used to measure the dimensional alveolar bone change is called "Integrated Distance" and it is expressed in mm3.

Time frame: From extraction to implant insertion (4 months)

Evaluation of new formed bone tissue

Evaluation of new formed bone tissue performed by histomorphometric methods.