The goal of this clinical trial is to determine whether boxing training reduces cardiovascular risk in elevated blood pressure or hypertension stage 1 individuals. The main questions it aims to answer are (1) if boxing training reduces peripheral and central blood pressure and (2) if boxing training improves cardiovascular function in elevated blood pressure or hypertension stage 1 individuals. Participants with elevated blood pressure or hypertension stage 1 will be randomly divided into a control group or an intervention group. The latter group will be involved in boxing training, 3 days per week for 6 weeks. Researchers will compare clinical and cardiovascular outcomes between the control and the intervention group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
24
The boxing training intervention will consist of three exercise sessions per week on nonconsecutive days for six weeks. Participants will be instructed to complete 10 rounds of three minutes with a one-minute resting period interspersed. Four rounds will consist of heavy bag punching (e.g. straight, jab, hook) at 60% VO2max and three rounds at 90-95% VO2max, while the remaining 3 rounds will be focused on mitt work at 60% VO2max.
The control group will perform three days per week 10 minutes of dynamic articular movement, five minutes of uni pedal stance, and five minutes of stretching of the upper limbs for six weeks.
The University of Texas at El Paso
El Paso, Texas, United States
Change from baseline brachial blood pressure after week six
Resting systolic and diastolic blood pressure (mmHg)
Time frame: pre-intervention and immediately after the intervention
Central Blood Pressure
Pulse wave analysis (mmHg)
Time frame: pre-intervention and immediately after the intervention
Vascular function
Flow mediated dilation (%)
Time frame: pre-intervention and immediately after the intervention
Plethysmography
Forearm and Calf Blood Flow (ml/min/100 ml tissue)
Time frame: pre-intervention and immediately after the intervention
Maximum Oxygen Uptake
Cardiopulmonary Test (ml/kg/min)
Time frame: pre-intervention and immediately after the intervention
Nitric Oxide Bioavailability
Blood Biomarker NOx (μmol/L)
Time frame: pre-intervention and immediately after the intervention
Body Fat Percentage
Dual energy x-ray absorptiometry Scan to assess Body Fat %
Time frame: pre-intervention and immediately after the intervention
Lean Mass
Dual energy x-ray absorptiometry Scan to assess lean mass (kg)
Time frame: pre-intervention and immediately after the intervention
Quality of Life measured by the short-form 36 (SF-36)
The short form 36 (SF-36) is a short survey that covers a total of 8 sub-dimensions related to physical and mental health: (1) Physical Functioning, (2) Role Limitations due to Physical Problems, (3) Social Functioning, (4) Bodily Pain, (5) General Mental Health, (6) Role Limitations due to Mental Problems, (7) Vitality, and (8) General Health Perceptions. The SF-36 includes a diverse mixture of continuous item scaling methods and is comprised of 10 items with balanced multi-item response formats (range from 1 to 5), 7 items with a dichotomous response format (1 or 2), and 19 items with non-balanced multi-item response formats (nine items range from 1 to 3 and ten items range from 1 to 6). To obtain the raw score for each sub-dimension, 10 items are reversed. Then, raw values for each sub-dimension are summed. Finally, the raw scores are transformed to a 0-to-100 scale for each sub-dimension. Higher scores indicate higher Quality of Life from 0 (worst) to 100 (best).
Time frame: pre-intervention and immediately after the intervention
Arterial Stiffness
Pulse wave velocity from carotid to femoral artery (m/s)
Time frame: pre-intervention and immediately after the intervention
C Reactive Protein (CRP) to assess inflammation
Blood Biomarker CRP (mg/L)
Time frame: pre-intervention and immediately after the intervention
Interleukin-6 (IL-6) to assess inflammation
Blood Biomarker IL-6 (pg/ml)
Time frame: pre-intervention and immediately after the intervention
Tumor necrosis factor alfa (TNFα) to assess inflammation
Blood Biomarker TNFα (pg/ml)
Time frame: pre-intervention and immediately after the intervention
8-isoprostane to assess inflammation
Blood Biomarker 8-isoprostane (pg/ml)
Time frame: pre-intervention and immediately after the intervention
Superoxide dismutase (SOD) to assess oxidative stress
Blood Biomarker SOD (mU/ml)
Time frame: pre-intervention and immediately after the intervention
Total Antioxidant Capacity (TAC) to assess oxidative stress
Blood Biomarker TAC (mM/ml)
Time frame: pre-intervention and immediately after the intervention
Lipid Profile
Blood Biomarkers HDL-C, LDL-C, and total cholesterol (mg/dl)
Time frame: pre-intervention and immediately after the intervention
Weight
Weight in kilograms
Time frame: pre-intervention and immediately after the intervention
Height
Height in meters
Time frame: pre-intervention and immediately after the intervention
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