Safety and Tolerability of IBI355 in Healthy Volunteers

Inclusion Criteria: 1. Understanding and Signing a written informed consent prior to selection; 2. Aged above 18 years old, male or female; 3. Body mass index (BMI) between 18-28kg/m2; 4. Normal label test; 5. No parenting plan for at least 6 months Exclusion Criteria: 1. Subjects with a history of allergy； 2. Subjects participated in the other clinical trail in 1 month or less than 5 t1/2 since the previous clinical trial (which is longer)； 3. Subjects with an infection requiring systemic medication was present within 30 days prior to randomization; 4. HIV-Ab、RPR、HCV-Ab、HBV、HBeAg or HBcAb, one of them positive; 5. There have a clinical or imaging evidence that the subject with active tuberculosis, or there is evidence that the subject is in the incubation period for tuberculosis; 6. Patients with a history of central nervous system, cardiovascular system, digestive system, respiratory system, urinary system, blood system, metabolic disorders and other systemic diseases; 7. Subject with a hcg positive; 8. Patients with a history of neuropsychiatry or who are considered unfit to participate in this clinical trial