This study investigates how brain activity and breathing changes in premature babies when their dose of caffeine treatment is changed or stopped. The study will assess premature babies receiving caffeine treatment as part of their clinical care. Brain activity will be recorded just before caffeine dose is changed and again two days afterwards. Breathing and other 'vital signs' (breathing rate, heart rate, oxygen saturation) will be recorded from the baby's monitor between the recordings of brain activity and for up to two weeks afterwards.
Study Type
OBSERVATIONAL
Enrollment
30
We will record infant\'s brain activity and vital signs when caffeine dose is changed or caffeine treatment is stopped. The decision to change dose/stop treatment will be made by the clinical team as part of routine care. No changes in caffeine treatment will be carried out solely for research purposes.
Newborn Care Unit, John Radcliffe Hospital
Oxford, Oxfordshire, United Kingdom
RECRUITINGRespiration
Change in respiratory dynamics between baseline (time at which caffeine dose is changed/treatment ends) and approximately 2 days later
Time frame: From baseline to two days later
Brain activity
Change in EEG activity between baseline (time at which caffeine dose is changed/treatment ends) and approximately 2 days later
Time frame: From baseline to two days later
Heart rate
Change in heart rate between baseline (time at which caffeine dose is changed/treatment ends) and approximately 2 days later
Time frame: From baseline to two days later
Oxygen saturation
Change in oxygen saturation between baseline (time at which caffeine dose is changed/treatment ends) and approximately 2 days later
Time frame: From baseline to two days later
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