Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia

Early Phase 1RecruitingNCT06417177

University of Missouri-Columbia75 enrolled

Overview

The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Aging Menopause Hypoxia Vasodilation

Interventions

PlaceboDRUG

Participants will receive a placebo in pill form.

PropranololDRUG

Participants will receive oral propranolol (1 mg/kg).

GemtesaDRUG

Participants will receive oral gemtesa (75 mg).

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Female assigned at birth * Pre, peri- or post-menopausal * Healthy weight (BMI ≥18 and ≤30 kg/m2) Exclusion Criteria: * Male (assigned at birth) * Pregnancy, breastfeeding * Use of hormone replacement therapies * Hysterectomy * Body mass index \>30 kg/m2 * Diagnosed sleep apnea * Current smoking/Nicotine/Drug use * Nerve/neurologic disease * Cardiovascular, hepatic, renal, respiratory disease * Blood pressure ≥140/90 mmHg * Diabetes, Polycystic ovarian syndrome * Communication barriers * Prescription medications * Malignant cancer

Locations (1)

University of Missouri-Columbia

Columbia, Missouri, United States

RECRUITING

Outcomes

Primary Outcomes

Forearm blood flow

Blood flow in the forearm measured with venous occlusion plethysmography.

Time frame: Change from baseline to 5 minutes.

Central Contacts

Jacqueline Limberg

CONTACT

573-882-2544 limberglab@missouri.edu

Data from ClinicalTrials.gov

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