Effect of TCI Propofol on Liver Transplant (TCI) Propofol on Intra-operative Usage of Vasopressors in Liver Transplant Recipients.

Phase 3RecruitingNCT06418893

Institute of Liver and Biliary Sciences, India60 enrolled

Overview

Both isoflurane and propofol are being used to give anaesthesia for living donor liver transplant in our institute. Propofol when compared to isoflurane has advantages like early awakening from anaesthesia, reduced nausea, vomiting in the postoperative period. Propofol also has antioxidant properties. Because of its antioxidant properties propofol may have a protective effect against oxidative stress and ischemia reperfusion injury in major organs during liver transplant surgery. However, there are no studies showing the effect of isoflurane and propofol on Intraoperative hemodynamics and postoperative liver and kidney functions.Thus, we are conducting this study to know the effect of these agents on intraoperative hemodynamics and postoperative liver and kidney function.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Liver Transplant Recipients

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 Years

Medical Language ↔ Plain English

Inclusion Criteria:-Above 18 years of age who will undergo living donor liver transplant \- Exclusion Criteria: Refusal to consent * Acute liver failure, Acute on chronic liver failure * Allergic to propofol or any component of propofol * Patients with pre existing cardiac dysfunction and cardiomyopathy * Patients with pre existing renal dysfunction/ deranged RFTs preoperatively

Outcomes

Primary Outcomes

Comparison of total Noradrenaline and vasopressin requirement between isoflurane and TCI propofol group in Living donor liver transplant recipients intraoperatively.

TCI propofol will provide more stable hemodynamics

Time frame: INTRAOPERATIVELY

Secondary Outcomes

To compare between the two groups mean arterial pressure during different phases of liver transplant recorded every 15 minutes

Time frame: INTRAOPERATIVELY AT 15 MINUTES INTERVAL

To compare between the two groups mean systemic vascular resistance during different phases of liver transplant recorded every 15 minutes

Time frame: INTRAOPERATIVELY AT 15 MINUTES INTERVAL

To compare between the two groups cardiac output during different phases of liver transplant recorded every 15 minutes

Time frame: INTRAOPERATIVELY AT 15 MINUTES INTERVAL

Total vasopressor requirement during reperfusion

Time frame: Intraoperative

Peak dose of nordrenaline and vasopressin during different phases of liver transplant intraoperatively

Time frame: Intraoperatively

QTc interval between the two groups during different phases of liver transplant measured every 15 minutes

Time frame: Intraoperatively every 15 mins

Peak lactate levels intraoperatively

Time frame: Intraoperatively

Postoperative Liver function tests ie Bilirubin and albumin