Exploring the effect of remimazolam dose on paradoxical reactions in pediatric painless gastrointestinal endoscopy.
Exploring the effect of remimazolam dose on paradoxical reactions and sedation in pediatric painless gastrointestinal endoscopy, observing the performance and duration of paradoxical reactions, and analyze the factors.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
333
Observe the incidence of paradoxical reactions after the first induction.
Tongji hospital
Wuhan, Hubei, China
incidence of paradoxical reaction
observe the incidence of paradoxical reaction within 2 minutes
Time frame: 2 minutes after first infusion of remimazolam
performance and duration of paradoxical reaction
observe the performance and duration of paradoxical reaction within 2 minutes
Time frame: 2 minutes after first infusion of remimazolam
dosage of sedative drugs
Total dose of the first administered plus supplemental doses of sedative drugs.
Time frame: First infusion until end of remimazolam administration
time records
anesthesia time, induction time, surgical time, awakening time, and recovery time
Time frame: 1 day
Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]
respiratory suppression incidence;intraoperative blood pressure and heart rate changes: record the patient's intraoperative blood pressure, heart rate, and the use of related vasoactive drugs; postoperative adverse reactions: such as hypertension, hypotension, tachycardia, gastrointestinal symptoms, postoperative restlessness, etc.
Time frame: 1 day
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