The Dual Impact of Cirrhosis on Transplantation for Hepatocellular Carcinoma：a Two-center Retrospective Cohort Study in China

N/ACompletedNCT06420791

Xiao Xu1 enrolled

Overview

Background: This study aims to investigate the correlation between cirrhosis and hepatocellular carcinoma (HCC) recurrence after Liver Transplantation. Methods: The study retrospectively collected data enrolled from 519 HCC patients who underwent liver transplantation from two center(the First Affiliated Hospital, Zhejiang University School of Medicine and Shulan (Hangzhou) Hospital, January 2015 to December 2020), Based on important variables, 1:3 propensity score matching (PSM) were performed respectively.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hepatocellular Carcinoma Cirrhosis

Interventions

OTHER

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: The patients undergoing liver transplantation for HCC from January 2015 to December 2020. Exclusion Criteria: Re-transplantation or combined liver-kidney transplantation; incomplete laboratory or clinical data; death within 90 days.

Outcomes

Primary Outcomes

The overall survival rate was evaluated by follow-up investigation and outpatient review

Time frame: 2-5 years

Secondary Outcomes

The tumor-free survival rate was evaluated by follow-up investigation and outpatient review