The goal of this interventional study is to learn if accelerated Intermittent Theta Burst Stimulation can improve symptoms of 30 participants with Unipolar depression in higher manner than symptoms of 30 participants with bipolar depression
We will apply stimulatory TMS protocol for participants with Unipolar depression and participants with bipolar depression using MagVenture MagPro R30 stimulator with the Cool-B65 coil
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
Stimulatory TMS protocol using MagVenture MagPro R30 stimulator with the Cool-B65 coil
Stimulatory TMS protocol using MagVenture MagPro R30 stimulator with the Cool-B65 coil
Mansoura University
Al Mansurah, Egypt
Comparison of severity of manic symptoms before and after treatment
We will use Young Mania Rating Scale.\_Young Mania Rating Scale:assess severity of manic symptoms, clinician rated,\<=12(remission)13\_19(minimal symptoms)20\_25(mild mania)26\_37(moderate mania)38\_60 severe mania
Time frame: One year for completion of the study
Comparison of the severity of the patient's illness at the time of assessment relative to the clinician's past experience with patients who have the same diagnosis.
We will use Clinical Global Impression Severity Scale.\_Clinical Global Impression Severity Scale:rate the severity of the patient's illness at the time of assessment relative to the clinician's past experience with patients who have the same diagnosis,1 normal not at all ill,2 borderline mentally ill,3 mildly ill,4 moderately ill,5 markedly ill,6 severely ill,7 extremely ill
Time frame: One year for completion of the study
Comparison of severity and impact of insomnia before and after treatment
We will use Insomnia Severity Index scale.\_Insomnia Severity Index:assess the nature, severity and impact of insomnia,0\_7(absence insomnia) 8\_14(subthreshold insomnia)15\_21(moderate insomnia)22\_28(severe insomnia)
Time frame: One year for completion of the study
Comparison of depressive symptoms before and after treatment
We will use Hamilton Depression Rating Scale.\_Hamilton Depression Rating Scale:assess the severity of depressive symptoms, clinician rated,0\_7(normal range)8\_16(mild severity)17\_23(moderate severity)\>23(severe depression)
Time frame: One year for completion of the study
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