Effects of TRE With Lactobacillus Plantarum LP-KFY04 Supplementation on Overweight / Obese Individuals

Inclusion Criteria: 1. Men or women aged 18 to 65 years old 2. BMI 24.0 to 40kg/m2 3. Patients who are aware of the purpose of the trail, willing to participate in the trial and sign informed consent forms, and comply with all requirements (including those during follow-up and evaluation investigations) Exclusion Criteria: 1. History of HIV, hepatitis B or C (self-report) or active pulmonary tuberculosis; 2. Diagnosis of type 1 or type 2 diabetes and prescribing hypoglycemic therapy 3. History of malignant tumors 4. Serious liver dysfunction or chronic kidney disease (aspartate aminotransferase (AST) or alanine transaminase (ALT) \> 3 times the upper limit of normal, or estimated glomerular filtration rate (eGFR) \< 30 ml/min/1.73 m2) 5. History of serious cardiovascular or cerebrovascular disease (angina, myocardial infarction, or stroke) within the past 6 months 6. History of serious gastrointestinal disease or gastrointestinal surgery within the past 12 months 7. History of Cushing's syndrome, hypothyroidism, acromegaly, and hypothalamic obesity 8. Smoking or have smoked within the past 3 months of the screening period 9. Drinking alcohol or drinking more than 15 grams of alcohol per day within the past 3 months of the screening period 10. Taking any medicine that may affect weight or metabolism within the past 6 months, including weight loss medications, antipsychotics, or other medications identified by the researchers 11. Currently involving in a weight loss program or having significant weight change within the past 3 months (\> 5% of current weight) 12. Women who are pregnant or planning for pregnant 13. Patients who are unable to complete 12-week follow-up (due to health conditions or immigration reasons) 14. Patients who are unwilling or unable to provide informed consent