Blood concentrations of Ciprofol were measured at different time points after single injection in patients with hypoproteinemia
This study was a single-center, interventional clinical study. Patients with different plasma albumin levels were selected before surgery and induced by a single injection of Ciprofol at a depth of 0.3 mg/kg. 2ml of venous blood was collected before and 0.5, 1, 2, 3, 5, 8, 15, 30min, 1h, 2h and 4h after administration. The pharmacokinetics of Ciprofol were studied by measuring the concentration of Ciprofol in blood.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
36
Patients who intended to undergo elective surgery under general anesthesia were induced by a single intravenous injection of 0.3mg/kg and ciprofol, and the experimental drug was manually injected by CVC within 30s. 2ml of venous blood was collected before and after administration 0.5min, 1min, 2min, 3min, 5min, 8min, 15min 30min, 1h, 2h and 4h respectively. The concentration of cyclopofol in blood was measured
Zhejiang Cancer Hospital
Hangzhou, Zhejang, China
Blood concentrations at different time points after a single injection
Blood concentration of ciprofol
Time frame: Before administration, after administration 0.5 minute, 1 minute, 2 minutes, 3 minutes, 5 minutes, 8 minutes, 15 minutes, 30 minutes, 1 hour, 2 hours, 4 hours
Onset time of ciprofol in patients with hypoproteinemia
The time it takes for the blood concentration of a drug to reach the clinically active concentration level from zero
Time frame: Day 1
Effect time of ciprofol in patients with hypoproteinemia
From the time the drug was administered to the time the patient lost consciousness
Time frame: Day 1
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