This project tests whether individuals with overweight or obesity and high craving can learn to change their brain response to food cues using neurofeedback, to impact their craving and eating behavior.
Aim 1 of this study is to test whether neurofeedback from the craving network is associated with reduced craving network strength. Aim 2 of this study is to test whether neurofeedback from the craving network is associated with reduced food craving and changes in eating behavior. Aim 3 of this study is to test whether neurofeedback from the craving network is associated with changes in resting state functional connectivity.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
50
Participants provided with feedback of target brain activation patterns (e.g., thermometer) and will be instructed to try to change the feedback (e.g., decrease the thermometer).
Participants provided with control (sham, yoked to another participant) feedback (e.g., thermometer) and will be instructed to try to change the feedback (e.g., decrease the thermometer).
Yale MRRC Anlyan Center
New Haven, Connecticut, United States
RECRUITINGChange in craving network strength during transfer runs
Craving network strength will be measured during transfer (i.e., no feedback) runs and compared across scan sessions.
Time frame: Week 1 and 3
Change in Food Craving Inventory Mean Score
Food Craving Inventory has 28 items rated 1-5 and overall mean is calculated, range 1-5 with higher score indicating higher craving. FCI will be compared between baseline and 1 month follow-up.
Time frame: Week 1, Week 7
Change in Automated Self-Administered 24-hour (ASA24®) Dietary Assessment Tool Healthy Eating Index (HEI).
ASA-24 HEI is scored 0-100 with 100 indicating healthier diet and composite scores examined to interpret the overall score. HEI will be compared between baseline and 1 month follow-up.
Time frame: Week 1, Week 7
Change in craving network strength during resting state runs
Craving network strength will be measured during resting state runs and compared across scan sessions.
Time frame: Week 1 and 3
Change in Food Rating Task healthiness, tastiness, and choice scores
Food Rating Task outcomes include healthiness, tastiness, and choice. Healthiness and tastiness mean score is taken, range 1-5, with 5 indicating higher healthiness or tastiness. Choice is counted from 0-48 items choosing the food item over the neutral reference food item, with higher values indicating more frequent choice. Food Ratings will be compared between baseline and 1 month follow-up.
Time frame: Week 1, Week 7
Change in Food Snack Task caloric intake
Food Snack Task will be used to measure caloric intake (out of a maximum value to calories offered) and compared across scan sessions.
Time frame: Week 1 and 3
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