Mechanisms Underlying Cardiovascular Consequences Associated With COVID-19 and Long COVID

Columbia University

Overview

AIM 1. Characterize cardiovascular phenotypes of long COVID by cardiopulmonary, meta-bolic, and cardiac mechanical/physiological responses to exercise and microvascular vasomotor function. AIM 2. Identify intercellular signaling between immune cells and cardiac cells associated with microvascular phenotypes of long COVID.

As many as 40-60% of patients who recovered from mild or moderate acute COVID have reported what is now called long COVID - multiple, persistent or recurrent symptoms lasting 6-9 months (or longer) following initial illness.1-4 Fatigue, dyspnea, and chest pain are the most common symptoms. Others include palpitations, lightheadedness, and syncope. All these cardiovascular symptoms can be debilitating, resulting in worse quality of life and morbidity.5, 6 Treatment options are limited.

Study Type

OBSERVATIONAL

Conditions

COVID-19

Eligibility

Sex: ALLMin age: 19 YearsMax age: 74 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18, \< 75 yrs * History of lab-confirmed COVID * Symptomatic at \>12 wks post-acute COVID (cases) * Recovered by 8wks post-acute COVID (controls) Exclusion Criteria: * Any history of critical illness * Chronic kidney disease, Stage \>4 * Pre-COVID: HFrEF, CABG, arrhythmia; pulmonary hypertension, pulmonary embolus, interstitial lung disease (ILD), O2 dependence; dementia, stroke, autonomic dysfunction; coagulopathy * Post-COVID: ILD, O2 dependence

Locations (1)

CUIMC

New York, New York, United States

Outcomes

Primary Outcomes

Prevalence of Microvascular dysfunction

This is to measure the microvascular dysfunction in patients using Cardiac PET.

Time frame: Up to 2.5 years

Data from ClinicalTrials.gov

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