The goal of this observational study is to evaluate the inflammatory saliva biomarkers in depression and gingivitis. The main question will be ; Will there be an increase at salivary biomarkers with depression patients and is it associated with gingivitis?
Background: The neuroimmune regulation disorder in depression patients causes the progression of inflammatory periodontal disease. The present study was to evaluate the periodontal health status and the levels of Triggering receptor expressed on myeloid cells 1 (TREM-1), peptidoglycan recognition protein 1 (PGLYRP1) and interleukin-1 beta (IL-1β) in individuals diagnosed with depression and to compare these findings with those of systemically healthy individuals. Methods: Forty-two depression patients were classified in two groups: depression with gingivitis (DG) and depression with periodontally healthy (DPH) patients. Additionally, 23 systemically and periodontally healthy (SPH) individuals were enrolled to the study. Periodontal parameters were recorded. Saliva samples were collected and salivary levels of TREM-1, PGLYRP1, IL-1β were measured using Enzyme-linked Immunosorbent Assay (ELISA) kits. depression regardless of periodontal status.
Study Type
OBSERVATIONAL
Enrollment
65
Clinical periodontal indices; Probing depth, Clinical attachment level, bleeding on probing, gingival index, and plaque
Duygu Ilhan
Istanbul, Select State, Turkey (Türkiye)
SalivaryTREM-1
Both, soluble and membrane-bound TREM-1, are detected by the TREM-1 ELISA.
Time frame: 06-09 2019
Salivary PGLYRP1
Both, soluble and membrane-bound PGLYRP1 are detected by the PGLYRP1 ELISA.
Time frame: 06-09 2019
Salivary IL-1β
Both, soluble and membrane-bound IL-1β detected by the IL-1β ELISA.
Time frame: 06-09 2019
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.