Study on the Mechanism of Ganoderma Lucidum Spore Powder in the Treatment of Depression

Inclusion Criteria * patients with depressive symptoms after surgery for papillary thyroid carcinoma in the outpatient department of Zhejiang Cancer Hospital * Han nationality * No previous depression and other mental diseases * 18-80 years old * Women * BMI 19 \~ 24 Exclusion Criteria * suffering from other diseases of the intestinal system * Gastrointestinal surgery was performed before intervention * Including patients with other malignant tumors, who need chemotherapy, radiotherapy, biological therapy or traditional Chinese medicine treatment received antibiotics or microecological modulators within 3 months before the intervention * Acute intestinal obstruction * Patients with severe depressive symptoms who must receive antidepressant treatment organic diseases such as heart and brain diseases, brain trauma history of mental illness, use of psychoactive drugs such as drugs * Severe liver and kidney dysfunction * Pregnancy, lactation