The investigators matched BCS and mastectomy group using propensity scores and analyzed the recurrence and survival among the evenly matched patients in breast cancer patients with BRCA 1/2 mutations.
The purpose of study is to assess the oncologic safety of BCS in patients carrying BRCA1/2 mutations by comparing long-term outcomes with mastectomy. The investigators matched BCS and mastectomy group using propensity scores and analyzed the recurrence and survival among the evenly matched patients. By providing insights into the feasibility of BCS for patients with BRCA1/2 mutations, the investigators aim to present evidence to aid in surgical decision-making for the care of these patients.
Study Type
OBSERVATIONAL
Enrollment
4,010
Breast-conserving surgery, also known as breast-conserving therapy or lumpectomy, is a surgical procedure used to treat breast cancer while preserving as much of the breast tissue as possible. During this procedure, the surgeon removes the cancerous tumor along with a surrounding margin of normal tissue. The goal is to remove the cancerous cells while maintaining the appearance and function of the breast as much as possible.
Hanyang university hospital
Seoul, South Korea
Locoregional recurrence-free survival
Recurrence in breast or chest wall and/or regional lymph nodes
Time frame: Duration from diagnosis until the development of recurrence up to 10year
Distant recurrence-free survival
Recurrence in a distant organ
Time frame: Duration from diagnosis until the development of recurrence up to 10year
Recurrence-free survival
Any form of disease recurrence
Time frame: Duration from diagnosis until the development of recurrence up to 10year
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