This study aims to determine the cut-off values of the new oxygenation indices and further investigate their capabilities in diagnosing ARDS and predicting its severity in ICU. Additionally, the investigators aim to compare these results with conventional oxygenation and saturation indices.
Recent studies have shown that mechanical power (MP) values below 17 J/min and driving pressure (DP) values below 15 cmH2O reduce intensive care unit (ICU) mortality. Asar et al. have introduced six new oxygenation indices utilizing MP and DP instead of Pmean (OSI-MPtot, OI-MPtot, OSI-ΔPinsp, OI-ΔPinsp, OSI-MPdyn, OI-MPdyn). They compared the predictive abilities of these new indices for ICU mortality in Covid-ARDS (C-ARDS) patients with conventional oxygenation indices (P/F, SpO2/FiO2, OI, OSI, PaO2/(FiO2xPEEP), and SpO2/FiO2xPEEP). OI-ΔPinsp, OSI-ΔPinsp, and OSI-MPdyn indices exhibited the highest predictive power for ICU mortality. However, cut-off values for the diagnosis and severity determination (mild, moderate, and severe) of ARDS patients have not been investigated. In this study, our objective is to determine the cut-off values of the new oxygenation indices and further investigate their capabilities in diagnosing ARDS and predicting its severity in ICU. Additionally, the investigators aim to compare these results with conventional oxygenation and saturation indices.
Study Type
OBSERVATIONAL
Enrollment
2,000
Basaksehir Cam Sakura City Hospital
Istanbul, Turkey (Türkiye)
Oxygenation indices
It was aimed to compare the oxygenation indexes of the patients. It will be examined which of these indices is more effective in diagnosing ARDS.
Time frame: During 28 days in the intensive care unit
Other parameters
It was aimed to compare the sequential organ failure assessment scores of the patients. Score ranges from 0 (best outcome) to 24 (worst outcome) points.
Time frame: During 28 days in the intensive care unit
acute physiology and chronic health evaluation-II
It was aimed to compare the acute physiology and chronic health evaluation-II scores of the patients. Score ranges from 0 (best outcome) to 71 (worst outcome) points.
Time frame: During 28 days in the intensive care unit
Charlson comorbidity index scores
It was aimed to compare the Charlson comorbidity index scores of the patients. Based on the Charlson comorbidity index score, the severity of comorbidity was categorized into three grades: mild, with Charlson comorbidity index scores of 1-2; moderate, with Charlson comorbidity index scores of 3-4; and severe, with Charlson comorbidity index scores ≥5.
Time frame: During 28 days in the intensive care unit
Other parameters
It was aimed to compare the Charlson comorbidity index of the patients.
Time frame: During 28 days in the intensive care unit
arterial blood gas parameters
It was aimed to compare the pH of the patients.
Time frame: During 28 days in the intensive care unit
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arterial blood gas parameters
It was aimed to compare the base excess of the patients.
Time frame: During 28 days in the intensive care unit
arterial blood gas parameters
It was aimed to compare the lactate of the patients.
Time frame: During 28 days in the intensive care unit
arterial blood gas parameters
It was aimed to compare the partial oxygen pressure of the patients.
Time frame: During 28 days in the intensive care unit