* Weakly crossed-linked hyaluronic acid (HA) can be delivered through multiple injections into the dermal and subnormal layer to improve skin quality. However, this treatment comes with multiple bumps for several days. * Alternatively, HA can be delivered after CO2 laser or thulium laser pretreatment. As microscopic analysis after this treatment is limited, the object of the present study is to investigate the morphological cellular changes after CO2 laser and thulium laser delivered HA into human skin.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Enrollment
30
Probands will be treated with a CO2 laser. Afterwards a HA gel will be applied. To measure microscopic cellular changes, a multiphoton tomography will be used.
Probands will be treated with a thulium laser. Afterwards a HA gel will be applied. To measure microscopic cellular changes, a multiphoton tomography will be used.
University Medical-Center Hamburg-Eppendorf
Hamburg, Germany
RECRUITINGSize of intercellular spaces
Size of intercellular spaces after CO2 or thulium laser treatment compared to control.
Time frame: 30 minutes and 30 days after treatment.
Size of keratinocytes
Size of keratinocytes after CO2 or thulium laser treatment compared to control.
Time frame: 30 minutes and 30 days after treatment.
Size of hyaluronic acid granules
Size of HA granules after CO2 or thulium laser treatment compared to control.
Time frame: 30 minutes and 30 days after treatment.
Distribution of Hyaluronic Acid
Distribution though the epidermal and dermal layers after CO2 or thulium laser treatment compared to control.
Time frame: 30 minutes and 30 days after treatment.
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