Effects of Lean Beef Consumption on Cardiometabolic Health and Gut Microbiome

University of Missouri-Columbia90 enrolled

Overview

This study is investigating the benefits of lean beef consumption on cardiometabolic health and gut microbiome.

The study is a 6-wk randomized, controlled, and parallel arm clinical trial. Participants will be randomized to consume either lean grain-fed beef, lean grass-fed beef, or plant-based meat for 6 weeks. Outcomes assessed will include metabolic, inflammatory, and gut microbiome markers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Diet Intervention

Interventions

Lean (≥90%) Grass-Fed BeefOTHER

The specified amount will be 4 oz. per day or 28 ounces per week for participants with an energy requirement of 2000 kcal.

Lean (≥90%) Grain-Fed BeefOTHER

The specified amount will be 4 oz. per day or 28 ounces per week for participants with an energy requirement of 2000 kcal.

Plant-Based MeatOTHER

Plant-based meat would be macronutrient matched to the same quantities of meat prescribed for a given energy level.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age: 18-45 years of age * BMI: 18-35 kg/m2 * Willingness to consume study foods. * Willing to comply with study protocol. * Consistent diet and activity patterns for 4 weeks * Weight stable (≤5 kg change over the last 3 months) * Non-smoker \>1 year or more Exclusion Criteria: * Allergies to foods provided in the study * Diabetes * Gastrointestinal disease and/or bariatric surgery * Uncontrolled hypertension and blood pressure ≥ 180/110 * Illicit drug use * Recent consumption of antibiotics or probiotics * Recent start of medications that affect metabolism or appetite. * Recent blood donation * Drug therapy for coronary artery disease, peripheral artery disease, congestive - heart failure, or dyslipidemia * Pregnant or lactating individuals * Taste or smell disorders * High consumers of red meat or plant-based meat (≥ 4 times/week)

Locations (1)

University of Missouri-Columbia

Columbia, Missouri, United States

RECRUITING

Outcomes

Primary Outcomes

LDL-C concentrations

Lipid profile

Time frame: Baseline, week 6

Interleukin-6 concentrations

Inflammatory marker

Time frame: Baseline, week 6

Gut microbial alpha-diversity

Assessed via16S rRNA sequencing

Time frame: Baseline, week 6

Secondary Outcomes

HDL-C concentrations

Lipid profile

Time frame: Baseline, week 6

Total cholesterol concentrations

Lipid profile

Time frame: Baseline, week 6

Triglyceride concentrations

Lipid profile

Time frame: Baseline, week 6

Gut microbiome abundance

16S rRNA sequencing

Time frame: Baseline, week 6

LPS-binding protein concentration

Intestinal permeability marker

Time frame: Baseline, week 6

Glucose concentrations

Blood Glucose

Time frame: Baseline, week 6

Insulin concentrations

Insulin

Central Contacts

Jaapna Dhillon

CONTACT

573-884-2103 jdhillon@missouri.edu

Data from ClinicalTrials.gov

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