Even though the COVID-19 pandemic is no longer at its peak, the threat still lingers. Engaging in prospective surveillance studies will enable us to monitor the disease and prepare for any potential resurgence. COVID-19 surveillance studies are essential tools for policymakers to make informed decisions, allocate resources, and develop strategies to control the spread of the virus and protect public health. The objective of this surveillance study is to prospectively assess in-hospital severe morbidity related to COVID-19 infection in children who present to the Pediatric Emergency Department (ED). A prospective multicenter study will be conducted across eight EDs in Israel and five EDs in the United Kingdom. The study population will include children aged 16 years or younger with a severe acute COVID-19 infection. Confirmation of acute COVID-19 infection will be based on polymerase chain reaction nasopharyngeal swab testing. The study will also include patients diagnosed with multisystem inflammatory syndrome in children (MIS-C), as defined by the CDC.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SCREENING
Masking
NONE
Enrollment
500
The healthcare provider will gently insert the swab a short distance (1-1.5 cm for young children) into one nostril, reaching the back of the nasal cavity. The swab will then be gently rotated and rubbed for a few seconds to collect a sample of mucus. The same process may be repeated in the other nostril.
Haemek Medical Center
Afula, Israel
RECRUITINGSoroka Medical Center
Beersheba, Israel
RECRUITINGHadassah Medical Center
Jerusalem, Israel
RECRUITINGShaare Zedek Medical Center
Jerusalem, Israel
RECRUITINGMeir Medical Center
Kfar Saba, Israel
RECRUITINGSheba Medical Center
Tel Litwinsky, Israel
RECRUITINGSevere acute COVID-19 infection (SACI)
The percentage of patients diagnosed with SACI among all patients admitted to the Emergency Department
Time frame: Up to 16 weeks
Administration of low-flow oxygen therapy via nasal cannula or face mask
The percentage of COVID-19 patients treated with low-flow oxygen among all patients admitted to the Emergency Department
Time frame: Up to 12 weeks
Administration of high-flow oxygen via nasal cannula (HFNC), or administration of oxygen via bilevel or continuous positive airway pressure (CPAP) machine
The percentage of COVID-19 patients treated with HFNC or CPAP among all patients admitted to the Emergency Department
Time frame: Up to 12 weeks
Treatment with mechanical ventilation
The percentage of COVID-19 patients treated with mechanical ventilation among all patients admitted to the Emergency Department
Time frame: Up to 12 weeks
Treatment with extracorporeal membrane oxygenation (ECMO)
The percentage of COVID-19 patients treated with ECMO among all patients admitted to the Emergency Department
Time frame: Up to 8 weeks
Treatment with vasopressor support
The percentage of COVID-19 patients treated with vasopressor support among all patients admitted to the Emergency Department
Time frame: Up to 8 weeks
Length of ICU stay
Mean duration of ICU stay for patients admitted with COVID-19
Time frame: Up to 16 weeks
Length of hospital stay
Mean duration of hospital stay for patients admitted with COVID-19
Time frame: Up to 24 weeks
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