The goal of this pilot and feasibility study is to is to test the feasibility of conducting a cross-sectional study on adiposity and cardiometabolic and neurocognitive risk factors at Kings College Hospital NHS Foundation Trust (KCH). The main aim is to assess and compare anthropometric measurements of adiposity (weight, Body Mass Index (BMI), Waist Circumference (WC), Waist-to-Hip ratio (WHR), Neck circumference (NC)), liver fat (hepatic steatosis and fibrosis), cardiometabolic risk factors (dyslipidemia, insulin resistance, hypertension) and neurocognitive risk factors among participants, according to their ethnic background. Participants will come at KCH for one visit and will have their anthropometric measurements and cardio-metabolic profile assessed. They will also perform questionnaires on lifestyle, socio-economic status and neuro-cognitive health during their visit.
The first objective of this study is to test the feasibility of conducting a cross-sectional study on adiposity and cardiometabolic and neurocognitive risk factors at Kings College Hospital NHS Foundation Trust. The second objective is to assess and compare anthropometric measurements of adiposity (weight, Body Mass Index (BMI), Waist Circumference (WC), Waist-to-Hip ratio (WHR), Neck circumference (NC)), liver fat (hepatic steatosis and fibrosis), cardiometabolic risk factors (dyslipidemia, insulin resistance, hypertension) and neurocognitive risk factors among participants, according to their ethnic background. The third objective is to test the feasibility of assessing cognitive function, in relation to adiposity, by using standardised tests measuring cognitive function (MMSE, MoCA or an adapted version) among ethnic groups of various education levels and literacy, lifestyle and from different cultures. Our objective is also to test the feasibility of using lifestyle questionnaires \[Food Frequencies Questionnaires (FFQ) and International Physical Activity Questionnaires -(IPAQ-S)\] in various ethnic groups with regard to geographic variation (urban, rural).
Study Type
OBSERVATIONAL
Enrollment
10
King's College Hospital NHS Foundation Trust
London, United Kingdom of Great Britain and Northern Ireland, United Kingdom
ACTIVE_NOT_RECRUITINGKing's College Hospital NHS Foundation Trust
London, United Kingdom
RECRUITINGHeight
Measured without shoes and reported in centimeters
Time frame: 1 minute
Insulin resistance
random plasma glucose, glycated haemoglobin (HbA1c) using a blood test
Time frame: 10 minutes
Type 2 Diabetes
random plasma glucose, glycated haemoglobin (HbA1c) using a blood test
Time frame: 10 minutes
Hepatic steatosis, and stages of fibrosis
Assessed by a certified physician using transient elastography (TE) measurements using a Fibroscan (Model mini-430).
Time frame: 10 minutes
neurocognitive risk factors
Result below 25 on the Montreal Cognitive Assessment test (MoCA). No minimum results, normal is above or equal to 26. The lower the result is the more the participant is at risk of presenting any form of neuro-cognitive impairment.
Time frame: 15 minutes
Weight
Measured using an automatic scale, without shoes. Reported in kilograms.
Time frame: 1 minute
BMI
Will be calculated from weight and height results and will be presented in kg/m2.
Time frame: 30 seconds
Waist circumference
Will be measured with a tape around the middle point halfway between the top of the hips and the bottom of the ribs, at expiration. Will be reported in centimeters.
Time frame: 1 minute
Hip circumference
Will be measure with a tape around the widest part of the hips. Will be reported in centimeters.
Time frame: 1 minute
Dyslipidemia
Will be diagnosed from lipid levels reported in a blood test
Time frame: 10 minutes
Neck circumference
Will be measure with a tape around a point just below the larynx (Adam's Apple) and perpendicular to the long axis of the neck. The participant should look straight ahead during measurement, with shoulders down (not hunched). Round the neck measurement up to nearest ½ centimeters. Result will be reported in centimeters.
Time frame: 1 minutes
Waist-to-Hip ratio
Will be derived from waist circumference and hip circumference.
Time frame: 30 seconds
Waist-to-Height ratio
Will be derived from waist circumference and height.
Time frame: 30 seconds
Hypertension (estimated using blood pressure measurement)
blood pressure will consist of 3 systolic blood pressure and diastolic blood pressure measurements
Time frame: 10minutes
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