The pre-stage of Chronic Obstructive Pulmonary Disease (Pre-COPD) is challenging to diagnose. However, identifying Pre-COPD is a crucial step in the prevention and management of COPD. Endobronchial optical coherence tomography showed the value of diagnosis in Pre-COPD and COPD in previous researchs.
We recruited COPD patients (stage I-II, n=15; stage III-IV, n= 15), Pre-COPD (n= 20) and healthy never-smokers (healthy human, n=21). Age,gender,BMI, smoking history, spirometry, chest computed tomography (CT), bronchoscopy and EB-OCT were performed. Inner luminal area (Ai) and airway wall area (Aw) of bronchi which inner perimeter was 10mm, 20mm and 30mm were measured using EB-OCT respectively. By analyzing and studying the above situation, we aim to discover the application value of OCT in Pre-COPD
Study Type
OBSERVATIONAL
Enrollment
80
Placing the probe of OCT in RB10c through the working channel of bronchoscope for real time dynamic scanning and collecting OCT parameters from participants in different groups.
Sichuan Provincial People's Hospital
Chengdu, Sichuan, China
RECRUITINGRepresentative EB-OCT images of airway disorders
Representative EB-OCT images(airway remodeling, mucosa thickening ) in CP，Pre-COPD and COPD
Time frame: baseline
EB-OCT parameters in different stages of COPD
Inner luminal area (Ai，mm) and airway wall area (Aw,mm2) of bronchi which inner perimeter was 10mm, 20mm and 30mm were measured using EB-OCT respectively.
Time frame: baseline
Baseline clinical characteristics
Age（year）, gender(Male/female), smoking history(yes/no)
Time frame: baseline
BMI（Kg/m2)）
Time frame: baseline
pulmonary function test (FEV1 predicted %)
Baseline clinical characteristics
Time frame: baseline
FEV1/FVC ratio
Time frame: baseline
MMEF 25/75
Baseline clinical characteristics
Time frame: baseline
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