Comparison of bowel preparation using 2 liter polyethylene glycol regimen plus elobixibat Versus 4-Liter polyethylene glycol regimen. This study based on hypothesis that show Boston bowel preparation scale which 2L PEG regimen plus Elobixibat have result no significant difference from 4L PEG regimen
The trial study in participant who visit to Rajavithi hospital for indication of colonoscopy such as Colorectal cancer screening, Iron deficiency anemia, Chronic diarrhea, chronic constipation, abdominal pain, unintentional weight loss, History of stool occult blood test , abnormal finding from imaging Randomized participant as above in to two group as bowel preparation regimen Group 1 the participant recieved Polyethylene glycol 2 liter split dose plus Elobixibat 10 milligram. Group 2 the participant recieved Polyethylene 4 liter split dose Result of the study show the difference of 2 regimen of bowel preparation which regimen better than another by measuring cleanliness of bowel preparation. The cleanliness of bowel preparation measured by Boston bowel preparation scale
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
360
Take Elobixibat 10 mg, one day before colonoscopy at 8 a.m. Take Polyethylene glycol 1 Liter, one day before colonoscopy at 8 p.m. Take polyethylene glycol 1 Liter, at day of colonoscopy at 5 a.m.
Take Polyethylene glycol 2 Liter, one day before colonoscopy at 8 p.m. Take polyethylene glycol 2 Liter, at day of colonoscopy at 5 a.m.
Rajavithi Hospital
Bangkok, Thailand
RECRUITINGComparison efficacy of bowel preparation before colonoscopy between 2 group
Bowel preaparation measure by Boston bowel preparation scale
Time frame: During colonoscopy procedure
Overall procedural time of colonoscopy
Duration since start colonoscopy insertion until withdrawal endoscope
Time frame: During colonoscopy procedure
Cecal intubation rate
Perform successful endoscopy to cecum
Time frame: During colonoscopy procedure
Withdrawal time of colonoscopy
Duration since endoscopy withdrawal from cecum to anal canal
Time frame: During colonoscopy procedure
Adenoma detection rate
At least one adenoma presented in this colonoscopy
Time frame: During colonoscopy procedure
Patient satisfaction in their bowel preparation regimen
Satisfaction score evaluate by Linkert scale
Time frame: 1 day before colonoscopy
Adverse event in each group
Nausea, vomiting, abdominal pain, bloating, sleep disturbance, chest pain, dizziness, dyspnea, leg edema
Time frame: During 24 hour after taking bowel preparation
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