Role of Nanoemulsified Sesame Oil in Post-operative Care After Endoscopic Sinus Surgery

Mansoura University60 enrolled

Overview

The goal of our thesis is to design, develop and characterize a novel thermodynamically stable NE by spontaneous method intended for topical use. Subsequently, appraisal of nanoemulsified sesame oil formulation has been performed on the post-operative symptoms in CRS patients who have undergone ESS (endoscopic sinus surgery) combined with different types of nasal irrigation which may affect formulation efficacy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Chronic Rhinosinusitis (Diagnosis)

Interventions

application of different topical nasal solutionsOTHER

each group receives a type of nasal solution to detect if there is a difference in the outcomes in chronic rhinosinusitis patients

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patient age between 18 and 60 years old. 2. chronic rhinosinusitis patients who have undergone endoscopic sinus surgery. Exclusion Criteria: 1. Patients with history of allergy for sesame seed derivatives. 2. Patients with chronic diseases which affecting the process of healing (uncontrolled DM, renal failure and hepatic failure). 3. Patients with nasal granulomas. 4. Patients with invasive fungal rhinosinusitis. 5. Smokers. 6. Patients with history of radio and/or chemotherapy exposure. 7. Patients with systemic diseases affecting integrity of nasal mucosa (e.g. CF, scleroderma, Sjogren syndrome …).

Locations (1)

Mansoura University

Al Mansurah, Dakahliya, Egypt

Outcomes

Primary Outcomes

Sinonasal Outcome Test 22 (SNOT-22)

Time frame: weekly for three months

Lund-Kennedy endoscopic grading system

Time frame: once monthly for three months

Data from ClinicalTrials.gov

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