Some indicators generated from hemogram such as neutrophil/lymphocyte (NLR) have been suggested as biomarkers of systemic inflammation. Type I Modic changes (MCs) have inflammatory nature histologically and are more painful clinically than type II MCs. Therefore, we hypothesized that patients with type I MCs may have increased inflammatory biomarkers and low back pain than those with type II MCs. The aim of this study was to test this hypothesis.
Patients and Methods: A total of 48 patients with MCs (type I/type II=24/24) were included in this study. Their demographic, clinical and hematologic characteristics were recorded. A 10 cm Visual Analog Scale (VAS) was used to detect low back pain intensity. Systemic inflammatory biomarkers including NLR, monocyte/lymphocyte (MLR), platelet/lymphocyte (PLR), neutrophil/lymphocyte\*platelet (NLPR), systemic inflammatory index (SII), systemic inflammatory response index (SIRI), and aggregate index of systemic inflammation (AISI) were derived from whole blood cell count. Keywords: Neutrophil-to-lymphocyte ratio, inflammation, Modic changes, back pain.
Study Type
OBSERVATIONAL
Enrollment
48
hemogram
Harran University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Şanlıurfa
Sanliurfa, Turkey (Türkiye)
Hemogram-derived inflammation indexes
blood-based
Time frame: 10 minutes
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