Transcranial Direct Current Stimulation for Treatment of Acute Ischemic Stroke

Phase 2RecruitingNCT06440707

University of California, Los Angeles120 enrolled

Overview

Many patients with acute ischemic stroke are ineligible for currently available standard treatments (clot-busting medication, also known as intravenous thrombolytic or mechanical removal of a clot), and many are non-responders, resulting in a low rate of excellent outcomes, which necessitates the development of novel therapies. In this study, investigators are testing a new treatment in which a weak electrical current will be applied via scalp electrodes to increase collateral blood flow to the brain and rescue the brain tissue at risk of injury. The primary aim is to find an optimal dose of this therapy that is both adequately safe and effective on imaging markers of brain tissue rescue.

This multi-site, phase 2a, randomized, sham-controlled, adaptive study aims to identify an optimal dose of a new treatment, cathodal direct current stimulation or C-tDCS, for acute ischemic stroke. This new treatment involves applying a weak inhibitory electrical current to the brain via scalp electrodes in acute stroke patients. The weak electrical current will electrically protect the brain cells not receiving enough oxygen and nutrients due to blood vessel blockage and increase the collateral blood flow to the brain. The study primarily aims to find an optimal dose that shows adequate safety and effectiveness on markers of brain protection and collateral blood flow enhancement using brain scan. The investigators will ask acute stroke patients who arrive at the Emergency Departments of the University of California Los Angeles (UCLA), Duke, and Johns Hopkins Medical Center and are not candidates for clot removal procedure (endovascular thrombectomy) to participate in the study. The study enrolls patients in 2 subgroups depending on their eligibility for clot-busting medication, also known as thrombolytics (thrombolytic receiving and thrombolytic ineligible groups). Then, patients will be randomized in a 5 to 1 ratio to receive active stimulation versus sham (control with no stimulation). Amongst patients randomized to the active arm, different doses of electrical current will be tested in various ranks, increasing the strength and the total duration of the electrical current at higher ranks. Computer simulation techniques (Bayesian method) will decide which dose patients should be assigned. The deciding rules of whether to escalate versus de-escalate versus stay on the same dose rank will be the probabilities of brain bleeding of ≤40% and substantial rescue of brain tissue at risk of permanent injury of ≥70%. The functional features and rules of the mathematical technique (Bayesian) will justify enrolling up to 50 patients in each subgroup of lytic-receiving and non-lytic-receiving patients (a total of up to 100 patients in active groups). Additionally, 10 sham (control) patients will be enrolled in each subgroup (a total of up to 20 patients in sham groups). At 24-30 hours after the study stimulation, patients will receive a brain MRI to assess the presence of any brain bleed and how much brain tissue is rescued (primary aims), as well as to examine the additional effects of the study stimulation on brain collateral blood flow and the growth of the permanently damaged brain tissue. As part of the study's additional goals, the treatment's tolerability will be studied by asking patients about how they feel during and after each session. Patients will also be neurologically examined after each session. Four days after enrollment, a brief neurological assessment will be performed if the patient is still in the hospital. On day 30, patients will receive a call from research personnel to see how they are doing. On day 90, they will be asked to come to neurology clinic to be neurologically assessed. The information gathered from this study will be used to advance this new treatment to future larger studies.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * New focal neurologic deficit consistent with AIS * National Institute of Health Stroke Scale (NIHSS) ≥4 or NIHSS\< 4 in the presence of disabling deficit (a deficit that, if unchanged, would prevent the * patient from performing basic activities of daily living such as bathing, ambulating, toileting, hygiene, and eating or returning to work) * Age\>18 * Presence of any cortical vessel occlusion, including Internal Carotid Artery, branches of Middle Cerebral Artery, Anterior Cerebral Artery, Posterior Cerebral Artery, Posterior-Inferior Cerebellar Artery * Presence of salvageable penumbra with perfusion lesion volume to ischemic core volume ratio of ≥ 1.2 on multimodal imaging * Patient ineligible for endovascular thrombectomy per American Heart/Stroke Associations Guidelines * Patient is able to be treated with tDCS within 24 hours of last known well time * A signed informed consent is obtained from the patient or patient's legally authorized representative Additional inclusion criteria for non-thrombolytic patients • Patient ineligible for IV lytics per American Heart/American Stroke Associations National Guidelines Additional inclusion criteria for thrombolytic receiving patients * Patient eligible for tPA per Guidelines * Within 2-hours from intravenous thrombolytic start of administration Exclusion Criteria: * Acute intracranial hemorrhage * Presence of MRI and gadolinium contraindications including cardiac implantable devices, cochlear implant, implanted neurostimulation device, unremovable metallic body piercing, magnetic dental implants, drug infusion pumps, estimated glomerular filtration rate of less than 35 mL/min/1.73 m2, allergy to gadolinium * Evidence of a large Ischemic core volume more than equal to 100 cc * Presence of transcranial direct current stimulation contraindications - electrically or magnetically activated intracranial metal and non-metal implants. * Pregnancy * Signs or symptoms of acute myocardial infarction on admission * History of seizure disorder or new seizures with presentation of current stroke * Evidence of any other major life-threatening or serious medical condition that would prevent completion of the study protocol, including attendance at the 3-month follow-up visit * Concomitant experimental therapy * Preexisting scalp lesion at the site of the stimulation or presence of skull defects (may alter current flow * pattern) * Preexisting coagulopathy * Patients suspected of having infective endocarditis and ischemic stroke related to septic emboli * Patients suspected or known to be infected with coronavirus 2019 (COVID-19) * Patient with radiographic evidence or suspicion of chronic conditions that may predispose them to intracranial hemorrhage, including brain arteriovenous malformations, cerebral cavernous malformations, cerebral telangiectasia, multiple previous intracerebral hemorrhages (amyloid angiopathy) * Suspected cerebral vasculitis based on medical history and imaging * Suspected cysticercosis * Suspected cranial dural arteriovenous fistula * Cerebral venous thrombosis * Head trauma causing loss of consciousness, concussion, confusion, or a headache within the past 30 days * Patient has suffered a hemorrhagic or ischemic stroke within the last three (3) months * History of cancer known to cause hemorrhagic metastases, e.g., melanoma, renal cell carcinoma, * choriocarcinoma, thyroid carcinoma, lung carcinoma, breast carcinoma, and hepatocellular carcinoma * History of left atrial myxoma * Evidence of dissection in the intracranial cerebral arteries * Suspicion of aortic dissection * Significant mass effect with midline shift * The patient is in a coma

Outcomes

Primary Outcomes

Presence of Radiographic Intracranial Hemorrhage

Presence of any intracranial hemorrhage on brain MRI, including hemorrhagic infarction types 1,2 and parenchymal hematoma types 1 and 2.

Time frame: At 24-30 hour post-stimulation

Presence of Substantial Penumbra Salvage

Presence of substantial penumbra salvage on hemodynamic brain MRI is defined as the presence of salvage of more than equal to 40% of penumbra.

Time frame: At 24-30 hour post-stimulation

Secondary Outcomes

Frequency of Symptomatic Intracranial Hemorrhage-Safety Outcome

Number of patients with parenchymal hemorrhage type 2 associated with worsening ≥ 4 on the National Institute of Health Stroke Scale (NIHSS)). The National Institute of Health Stroke Scale is composed of 11 items, each of which scores a specific ability between a 0 and 4. For each item, a score of 0 typically indicates normal function in that specific ability, while a higher score is indicative of some level of impairment; a higher score indicates worse neurological deficits.The individual scores from each item are summed in order to calculate a patient's total NIHSS score. The maximum possible score is 42 (highest disability), with the minimum score being a 0 (lowest disability).

Time frame: At 24-30 hour post-stimulation

Frequency of Early Neurologic Deterioration-Safety Outcome

Number of patients with worsening of more than equal to 4 on the National Institute of Health Stroke Scale (NIHSS) during the 24-hour period after stimulation, with or without intracranial hemorrhage. The National Institute of Health Stroke Scale is composed of 11 items, each of which scores a specific ability between a 0 and 4. For each item, a score of 0 typically indicates normal function in that specific ability, while a higher score is indicative of some level of impairment; a higher score indicates worse neurological deficits.The individual scores from each item are summed in order to calculate a patient's total NIHSS score. The maximum possible score is 42 (highest disability), with the minimum score being a 0 (lowest disability).

Time frame: At 24-hour post-stimulation

All-cause Mortality -Safety Outcome

Number of patients with with outcome of death or modified Rankin Scale of 6

Time frame: At day 90 post-stimulation

Frequency of Completion of Stimulation Protocol-Tolerability Outcome

Number of participants who complete the protocol-assigned stimulation treatment without adverse effects as assessed by a modified Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events.

Time frame: At the end of each 20 minute stimulation period

Frequency and Severity of Adverse Events-Tolerability Outcome

Number of patients who experience adverse events as assessed by a modified Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events and severity of each event

Time frame: At the end of each 20 minute stimulation period

Amount of Collateral Enhancement- Imaging Efficacy Biomarker Outcome

Percent change in the quantitative relative cerebral blood volume of the ischemic region as an index of collateral enhancement from baseline to post-stimulation

Time frame: At 24-30 hour post-stimulation

Infarct Core Growth- Imaging Efficacy Biomarker Outcome

Change in the infarct core volume in milliliters from baseline to post-stimulation

Time frame: At 24-30 hour post-stimulation

Reduction in Ischemic Lesion- Imaging Efficacy Biomarker Outcome

Change in perfusion lesion (ischemic lesion with Tmax\>6sec) volume from baseline to post-stimulation

Time frame: At 24-30 hour post-stimulation

Transcranial Direct Current Stimulation for Treatment of Acute Ischemic Stroke

Overview

Conditions

Interventions

Eligibility

Locations (3)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts