Portal Vein Pulsatility Index to Assess Fluid Intolerance

Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu50 enrolled

Overview

This study uses the portal vein pulsatility index (PVPI) to assess fluid intolerance amongst fluid responders.

This prospective observational study aims to use the portal vein pulsatility index (PVPI) to assess fluid intolerance in fluid responders. The investigators will enroll mechanically ventilated postoperative adult patients within 6 hours of ICU admission after cardiac surgery. Patients will undergo a Passive Leg Raising (PLR) test and Left Ventricular Outflow Tract (LVOT) recording using transthoracic echocardiography. The main objective is to predict fluid intolerance after a fluid challenge of 7 ml/kg Ringer Lactate over 10 minutes in initially tolerant fluid responders.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Venous Congestion

Interventions

Ringer's Lactate Crystalloid SolutionsDRUG

7 ml/kg ml of Ringer's Lactate is given in 10 min amongst initially tolerant fluid responders.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Informed consent. * Mechanically ventilated patients within 6 hours after ICU admission following surgery who are considered for fluid administration to optimize haemodynamics. * Sinus rhythm. Exclusion Criteria: * A condition known to interfere with portal vein flow assessment or interpretation (liver cirrhosis or chronic hepatic disease, suprahepatic or portal vein thrombosis). * Any mechanical circulatory support. * Cardiac transplant. * Poor transthoracic echocardiographic window.

Locations (1)

"Prof CC Iliescu" Emergency Institue for Cardiovascular Diseases

Bucharest, Romania

Outcomes

Primary Outcomes

Fluid Intolerance

A portal vein pulsatility index greater than 50%, calculated as (Vmax - Vmin) / Vmax, with no upper limit and 0% as the minimum limit. Higher values indicate worse outcomes. Ultrasonographic portal spectral waveform was used to measure Vmax and Vmin.

Time frame: 10 minutes after 7 ml/kg Ringer's Lactate

Data from ClinicalTrials.gov

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