The main purpose of this study is to see how much of orforglipron (study drug) gets into the bloodstream and how long it takes the body to get rid of it when given as capsules compared to tablets in healthy overweight and obese participants. The safety and tolerability (side effects) of orforglipron when given as capsules and tablets will also be evaluated. The study will be conducted in two parts, with part A and B lasting up to approximately 25 and 22 weeks each respectively, including the screening period.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
533
Administered orally
Anaheim Clinical Trials, LLC
Anaheim, California, United States
Collaborative Neuroscience Research, LLC
Los Alamitos, California, United States
Fortrea Clinical Research Unit
Daytona Beach, Florida, United States
Altasciences Company Inc.
Overland Park, Kansas, United States
QPS
Springfield, Missouri, United States
Fortrea Clinical Research Unit
Dallas, Texas, United States
Fortrea Clinical Research Unit
Madison, Wisconsin, United States
Part B: Pharmacokinetics (PK): Steady-state Area Under the Concentration Time Curve From Time Zero to the End of the Dosing Interval, Tau (AUC[0-tau]) of LY3502970 on Day 7
PK: Area under the concentration versus time curve from time 0 to the end of the once daily dosing interval at steady state AUC\[0-tau\] on Day 7.
Time frame: Pre-dose, 0.5, 1, 2, 4, 6, 8, 12, 16 and 24 hours post-dose on Day 7 for each dosing treatment period (1 period=7 days)
Part B: PK: Steady-state Maximum Observed Concentration (Cmax) of LY3502970 on Day 7
PK: Maximum concentration of LY3502970 during a once daily dosing interval at steady state on Day 7.
Time frame: Pre-dose, 0.5, 1, 2, 4, 6, 8, 12, 16 and 24 hours post-dose on Day 7 for each dosing treatment period (1 period=7 days)
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